Biological systems are by nature multiscale, consisting of subsystems that factor into
progressively smaller units in a deeply hierarchical structure. At any level of the hierarchy …

INTRODUCTION Tumor genome sequencing has revealed that, beyond a few commonly
mutated genes, most mutations that affect cancer genomes are rare. To interpret these rare …

Phylogeny estimation (the reconstruction of evolutionary trees) has recently been applied to
CRISPR-based cell lineage tracing, allowing the developmental history of an individual …

Detection of community structure has become a fundamental step in the analysis of
biological networks with application to protein function annotation, disease gene prediction …

Patients with neurodevelopmental disorders, including autism, have an elevated incidence
of congenital heart disease, but the extent to which these conditions share molecular …

In any 'omics study, the scale of analysis can dramatically affect the outcome. For instance,
when clustering single-cell transcriptomes, is the analysis tuned to discover broad or specific …

In this chapter, we present a survey on various decision support methods that uses ontology
as its tool to provide the reasoning, medical knowledge list, attributes and relationship …

Mid-winter breakups (MWBs) are an increasingly common event on Canadian rivers
resulting in the early breakup of river ice cover, with complex and numerous drivers. This …

Background Discerning genes crucial to antimicrobial resistance (AMR) mechanisms is
becoming more and more important to accurately and swiftly identify AMR pathogenic …

Modernizing risk assessment methods that underlie risk management decisions developed
to protect public and environmental health will require interdisciplinary dialog and …