Interactions between dynamic microtubules and actin filaments are essential to a wide range
of cell biological processes including cell division, motility and morphogenesis. In neuronal …

The formation of a neurite, the basis for axons and dendrites, begins with the concerted
accumulation and organization of actin and microtubules. Whereas much is known about the …

We show that the splicing regulator PTBP2 controls a genetic program essential for neuronal
maturation. Depletion of PTBP2 in developing mouse cortex leads to degeneration of these …

Actin filaments form contractile and protrusive structures that play central roles in many
processes such as cell migration, morphogenesis, endocytosis, and cytokinesis. During …

Drebrin is an actin filament (F-actin)–binding protein with crucial roles in neuritogenesis and
synaptic plasticity. Drebrin couples dynamic microtubules to F-actin in growth cone filopodia …

Identification of actin-depolymerizing factor homology (ADF-H) domains in the structures of
several related proteins led first to the formation of the ADF/cofilin family, which then …

Dendritic spines form typical excitatory synapses in the brain and their shapes vary
depending on synaptic inputs. It has been suggested that the morphological changes of …

Drebrin is an actin‐binding protein that changes the helical pitch of actin filaments (F‐actin),
and drebrin‐decorated F‐actin shows slow treadmilling and decreased rate of …

Filopodia are finger-like cellular protrusions found throughout the metazoan kingdom and
perform fundamental cellular functions during development and cell migration. Neurons …

Neurons extend axons to form the complex circuitry of the mature brain. This depends on the
coordinated response and continuous remodelling of the microtubule and F-actin networks …