Sleep deprivation disrupts the lives of millions of people every day and has a profound
impact on the molecular biology of the brain. These effects begin as changes within a …

Growing evidence implicates the gut microbiome in cognition. Viruses, the most abundant
life entities on the planet, are a commonly overlooked component of the gut virome …

Metabolic production of acetyl coenzyme A (acetyl-CoA) is linked to histone acetylation and
gene regulation, but the precise mechanisms of this process are largely unknown. Here we …

Synaptic plasticity is the ability of synapses to weaken or strengthen over time, in response
to changes in the activity of the neurons. It is orchestrated by a variety of genes, proteins …

It is widely assumed that cells must be physically isolated to study their molecular profiles.
However, intact tissue samples naturally exhibit variation in cellular composition, which …

The importance of memory in bacterial decision-making is relatively unexplored. We show
here that a prior experience of swarming is remembered when Escherichia coli encounters a …

SETD5 gene mutations have been identified as a frequent cause of idiopathic intellectual
disability. Here we show that Setd5-haploinsufficient mice present developmental defects …

The sequencing of the full transcriptome (RNA-seq) has become the preferred choice for the
measurement of genome-wide gene expression. Despite its widespread use, challenges …

Aging weakens memory functions. Exposing healthy rodents or pathological rodent models
to environmental enrichment (EE) housing improves their cognitive functions by changing …

Memory consolidation involves discrete patterns of transcriptional events in the
hippocampus. Despite the emergence of single-cell transcriptomic profiling techniques …