Selection on synonymous sites: the unwanted transcript hypothesis
Although translational selection to favour codons that match the most abundant tRNAs is not
readily observed in humans, there is nonetheless selection in humans on synonymous …
readily observed in humans, there is nonetheless selection in humans on synonymous …
Landscape of adenosine-to-inosine RNA recoding across human tissues
O Gabay, Y Shoshan, E Kopel, U Ben-Zvi… - Nature …, 2022 - nature.com
RNA editing by adenosine deaminases changes the information encoded in the mRNA from
its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally …
its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally …
Identification of Bona Fide RNA Editing Sites: History, Challenges, and Opportunities
MH Tan - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by the adenosine
deaminase acting on the RNA (ADAR) family of enzymes of which there are three members …
deaminase acting on the RNA (ADAR) family of enzymes of which there are three members …
A novel computational method enables RNA editome profiling during human hematopoiesis from scRNA-seq data
RNA editing is a post-transcriptional modification with a cell-specific manner and important
biological implications. Although single-cell RNA-seq (scRNA-seq) is an effective method for …
biological implications. Although single-cell RNA-seq (scRNA-seq) is an effective method for …
[HTML][HTML] Divergent landscapes of A-to-I editing in postmortem and living human brain
M Rodriguez de los Santos, BH Kopell… - nature …, 2024 - nature.com
Abstract Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA
modification within the brain. Yet, most research has relied on postmortem samples …
modification within the brain. Yet, most research has relied on postmortem samples …
[HTML][HTML] Divergent landscapes of A-to-I editing in postmortem and living human brain
Abstract Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA
modification within the brain. Yet, most research has relied on postmortem samples …
modification within the brain. Yet, most research has relied on postmortem samples …
Profiling RNA editing in single cells
RNA editing is a widespread molecular phenomenon occurring in a variety of organisms. In
humans, it mainly involves the deamination of adenosine to inosine (A-to-I) in double …
humans, it mainly involves the deamination of adenosine to inosine (A-to-I) in double …
RNA Editing by ADAR Adenosine Deaminases in the Cell Models of CAG Repeat Expansion Diseases: Significant Effect of Differentiation from Stem Cells into Brain …
VV Kudriavskii, AO Goncharov, AV Eremeev… - Biochemistry …, 2024 - Springer
Expansion of CAG repeats in certain genes is a known cause of several neurodegenerative
diseases, but exact mechanism behind this is not yet fully understood. It is believed that the …
diseases, but exact mechanism behind this is not yet fully understood. It is believed that the …
Comparative functional RNA editomes of neural differentiation from human PSCs
Y Zhang, Q Zhang, Y Hou, R Wang, Y Wang - Life Medicine, 2022 - academic.oup.com
RNA editing is a fundamental mechanism that constitutes the epitranscriptomic complexity. A-
to-G editing is the predominant type catalyzed by ADAR1 and ADAR2 in human. Using a …
to-G editing is the predominant type catalyzed by ADAR1 and ADAR2 in human. Using a …
Generating human parvalbumin interneurons through 3D glia reprogramming
CA Stamouli, A Degener, E Cepeda-Prado, A Bruzelius… - bioRxiv, 2024 - biorxiv.org
Parvalbumin (PV) interneurons are crucial for synaptic plasticity, and their damage or loss is
linked to various neurological disorders. Yet, generating these cells of human source in vitro …
linked to various neurological disorders. Yet, generating these cells of human source in vitro …