Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …

Being isolated from the peripheral system by the blood–brain barrier, the brain has long
been considered a completely impervious tissue. However, recent findings show that the gut …

An increasing number of epidemiological studies have shown that there is a significant
inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) …

Alzheimer's disease (AD) is a central nervous system disease that can lead to cognitive
impairment and progressive memory loss. An increasing number of studies have shown that …

Alzheimer's disease (AD) has brought a heavy burden to society as a representative
neurodegenerative disease. The etiology of AD combines multiple factors, concluding …

Alzheimer's disease (AD) is characterized by complex, multifactorial neuropathology,
suggesting that small molecules targeting multiple neuropathological factors are likely …

In addition to cognitive decline, patients with Alzheimer's disease (AD) exhibit sensory,
motor, and neuropsychiatric deficits. Many AD patients also show weight loss, suggesting …

Elderly individuals frequently report cognitive decline, while various studies indicate
hippocampal functional declines with advancing age. Hippocampal function is influenced by …

Microglial polarization and ferroptosis are important pathological features in Alzheimer's
disease (AD). Ghrelin, a brain-gut hormone, has potential neuroprotective effects in AD. This …

Ghrelin is an octanoylated peptide acting by the activation of the growth hormone
secretagogue receptor, namely, GHS-R1a. The involvement of ghrelin in several …