Non‐small cell lung cancer in China

P Chen, Y Liu, Y Wen, C Zhou - Cancer Communications, 2022 - Wiley Online Library
In China, lung cancer is a primary cancer type with high incidence and mortality. Risk factors
for lung cancer include tobacco use, family history, radiation exposure, and the presence of …

[PDF][PDF] Pleiotropy and specificity: insights from the interleukin 6 family of cytokines

M Murakami, D Kamimura, T Hirano - Immunity, 2019 - cell.com
Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

J Byun, Y Han, Y Li, J Xia, E Long, J Choi, X Xiao… - Nature …, 2022 - nature.com
To identify new susceptibility loci to lung cancer among diverse populations, we performed
cross-ancestry genome-wide association studies in European, East Asian and African …

Risk factors for lung cancer worldwide

J Malhotra, M Malvezzi, E Negri… - European …, 2016 - Eur Respiratory Soc
Lung cancer is the most frequent malignant neoplasm in most countries, and the main
cancer-related cause of mortality worldwide in both sexes combined. The geographic and …

[PDF][PDF] 中国肺癌筛查与早诊早治指南(2021, 北京)

赫捷, 李霓, 陈万青, 吴宁, 沈洪兵, 江宇, 李江… - 中华肿瘤 …, 2021 - suanfayisheng.com
肺癌是中国发病率和死亡率最高的恶性肿瘤. 筛查与早诊早治是降低人群肺癌死亡率的有效措施
. 制定符合中国国情的肺癌筛查与早诊早治指南, 将极大推进中国肺癌筛查的同质性和优质性 …

Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations

J Dai, J Lv, M Zhu, Y Wang, N Qin, H Ma… - The Lancet …, 2019 - thelancet.com
Background Genetic variation has an important role in the development of non-small-cell
lung cancer (NSCLC). However, genetic factors for lung cancer have not been fully …

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

J Shi, K Shiraishi, J Choi, K Matsuo, TY Chen… - Nature …, 2023 - nature.com
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain
only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage …

Phosphoinositides: tiny lipids with giant impact on cell regulation

T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

Y Wang, JD McKay, T Rafnar, Z Wang, MN Timofeeva… - Nature …, 2014 - nature.com
We conducted imputation to the 1000 Genomes Project of four genome-wide association
studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 …

A decade of GWAS results in lung cancer

Y Bossé, CI Amos - Cancer Epidemiology, Biomarkers & Prevention, 2018 - AACR
Genome-wide association studies (GWAS) were successful to identify genetic factors
robustly associated with lung cancer. This review aims to synthesize the literature in this field …