Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

Neutrophils (also called polymorphonuclear leukocytes, PMNs) are the most abundant white
blood cells in humans and play a central role in innate host defense. Another distinguishing …

Autoantibodies against nucleic acids and excessive type I interferon (IFN) are hallmarks of
human systemic lupus erythematosus (SLE). We previously reported that SLE neutrophils …

Classical dendritic cells (cDC) are professional antigen-presenting cells (APC) that regulate
immunity and tolerance. Neutrophil-derived cells with properties of DCs (nAPC) are …

Neutrophils are key effector cells of the innate immune response and are required to migrate
and function within adverse microenvironmental conditions. These inflammatory sites are …

Exposure to pro-inflammatory cytokines, chemokines, mitochondrial contents, and bacterial
and viral products induces neutrophils to transition from a basal state into a primed one …

Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …

The mucosal immune system in the female reproductive tract (FRT) has evolved to meet the
unique requirements of dealing with sexually transmitted bacterial and viral pathogens …

Gene targeting of the adaptor molecule DAP12 in mice caused abnormal distribution and
impaired antigen presentation capacity of dendritic cells (DCs). However, the DAP12 …

Neutrophils are considered to be central to the pathogenesis of most forms of acute lung
injury (ALI). For the sake of clarity, neutrophil involvement in ALI can be conceptualized as …