YAP/TAZ at the roots of cancer

F Zanconato, M Cordenonsi, S Piccolo - Cancer cell, 2016 - cell.com
YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …

Cell motility in cancer invasion and metastasis: insights from simple model organisms

CH Stuelten, CA Parent, DJ Montell - Nature Reviews Cancer, 2018 - nature.com
Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …

The biology of YAP/TAZ: hippo signaling and beyond

S Piccolo, S Dupont, M Cordenonsi - Physiological reviews, 2014 - journals.physiology.org
The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …

Protein palmitoylation and cancer

PJ Ko, SJ Dixon - EMBO reports, 2018 - embopress.org
Protein S‐palmitoylation is a reversible post‐translational modification that alters the
localization, stability, and function of hundreds of proteins in the cell. S‐palmitoylation is …

Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss

G Arun, S Diermeier, M Akerman… - Genes & …, 2016 - genesdev.cshlp.org
Genome-wide analyses have identified thousands of long noncoding RNAs (lncRNAs).
Malat1 (metastasis-associated lung adenocarcinoma transcript 1) is among the most …

The mammalian blood-testis barrier: its biology and regulation

DD Mruk, CY Cheng - Endocrine reviews, 2015 - academic.oup.com
Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

ER Shamir, AJ Ewald - Nature reviews Molecular cell biology, 2014 - nature.com
Mammalian organs are challenging to study as they are fairly inaccessible to experimental
manipulation and optical observation. Recent advances in three-dimensional (3D) culture …

[HTML][HTML] The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

M Cordenonsi, F Zanconato, L Azzolin, M Forcato… - Cell, 2011 - cell.com
Cancer stem cells (CSCs) are proposed to drive tumor initiation and progression. Yet, our
understanding of the cellular and molecular mechanisms that underlie CSC properties is …

The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems

SE Leggett, AM Hruska, M Guo, IY Wong - Cell Communication and …, 2021 - Springer
The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the
intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated …

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

B Zhao, K Tumaneng, KL Guan - Nature cell biology, 2011 - nature.com
Precise control of organ size is crucial during animal development and regeneration. In
Drosophila and mammals, studies over the past decade have uncovered a critical role for …