Ischemic stroke (IS) has complex pathological mechanisms, and is extremely difficult to treat.
At present, the treatment of IS is mainly based on intravenous thrombolysis and mechanical …

Polymyxin B (PMB) is an essential antibiotic active against multidrug-resistant bacteria, such
as multidrug-resistant Pseudomonas aeruginosa (MDRP). However, the clinical use of PMB …

Background Neuroinflammation reportedly plays a critical role in the pathogenesis of sepsis-
associated encephalopathy (SAE). We previously reported that circulating plasma …

Human group IIA secreted phospholipase A2 (GIIA) is a key enzyme in inflammatory
reactions, worsening the condition of several chronic inflammatory diseases. The natural …

Methylmercury (MeHg) is a bio-accumulative global environmental contaminant present in
fish and seafood. MeHg accumulates in the aquatic environment and eventually reaches the …

Toxicological research is mostly limited to considering the effects of a single substance,
even though the real exposure of people is reflected in their daily exposure to many different …

Chronic mercury poisoning is the oldest occupational disease, and mercury is currently
among the top three chemicals of major public health concern. Moreover, all human beings …

Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) triggers a noncanonical form of
programmed cell death (PCD) called parthanatos, yet the mechanisms of its induction are …

Methylmercury (MeHg), a global environmental pollutant, could seriously damage the
central nervous system (CNS) and cause neurological disorders such as cerebellar …

Despite the potential toxicity of commercial chemicals to the development of the nervous
system (known as developmental neurotoxicity or DNT), conventional in vitro cell models …