EBV-associated diseases: Current therapeutics and emerging technologies
EBV is a prevalent virus, infecting> 90% of the world's population. This is an oncogenic virus
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …
How EBV infects: the tropism and underlying molecular mechanism for viral infection
The Epstein–Barr virus (EBV) is associated with a variety of human malignancies, including
Burkitt's lymphoma, Hodgkin's disease, nasopharyngeal carcinoma and gastric cancers …
Burkitt's lymphoma, Hodgkin's disease, nasopharyngeal carcinoma and gastric cancers …
[HTML][HTML] Epstein-Barr virus evades restrictive host chromatin closure by subverting B cell activation and germinal center regulatory loci
Chromatin accessibility fundamentally governs gene expression and biological response
programs that can be manipulated by pathogens. Here we capture dynamic chromatin …
programs that can be manipulated by pathogens. Here we capture dynamic chromatin …
[HTML][HTML] Epstein–Barr virus and genetic risk variants as determinants of T-bet+ B cell-driven autoimmune diseases
B cells expressing the transcription factor T-bet are found to have a protective role in viral
infections, but are also considered major players in the onset of different types of …
infections, but are also considered major players in the onset of different types of …
Epstein-Barr virus perpetuates B cell germinal center dynamics and generation of autoimmune-associated phenotypes in vitro
Human B cells encompass functionally diverse lineages and phenotypic states that
contribute to protective as well as pathogenic responses. Epstein-Barr virus (EBV) provides …
contribute to protective as well as pathogenic responses. Epstein-Barr virus (EBV) provides …
Epstein–Barr virus infection, B‐cell dysfunction and other risk factors converge in gut‐associated lymphoid tissue to drive the immunopathogenesis of multiple …
Multiple sclerosis is associated with Epstein–Barr virus (EBV) infection, B‐cell dysfunction,
gut dysbiosis, and environmental and genetic risk factors, including female sex. A disease …
gut dysbiosis, and environmental and genetic risk factors, including female sex. A disease …
A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populations
C Cantoni, RA Smirnov, M Firulyova, PS Andhey… - The Journal of Clinical …, 2025 - jci.org
Single-cell transcriptomics applied to cerebrospinal fluid (CSF) for elucidating the
pathophysiology of neurologic diseases has produced only a preliminary characterization of …
pathophysiology of neurologic diseases has produced only a preliminary characterization of …
Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression
ED SoRelle, LE Haynes, KA Willard, B Chang… - PLoS …, 2024 - journals.plos.org
Viral infection leads to heterogeneous cellular outcomes ranging from refractory to abortive
and fully productive states. Single cell transcriptomics enables a high resolution view of …
and fully productive states. Single cell transcriptomics enables a high resolution view of …
Multiple sclerosis patient-derived spontaneous B cells have distinct EBV and host gene expression profiles in active disease
Epstein–Barr virus (EBV) is an aetiologic risk factor for the development of multiple sclerosis
(MS). However, the role of EBV-infected B cells in the immunopathology of MS is not well …
(MS). However, the role of EBV-infected B cells in the immunopathology of MS is not well …
BCR signaling is required for posttransplant lymphoproliferative disease in immunodeficient mice receiving human B cells
T Zhang, RYH Cheng, AR Ott, NP Dahl… - Science Translational …, 2024 - science.org
Posttransplant lymphoproliferative disease (PTLD) is a major therapeutic challenge that has
been difficult to study using human cells because of a lack of suitable models for …
been difficult to study using human cells because of a lack of suitable models for …