Anabolic–androgenic steroids (AAS) are a class of hormones that are widely abused for
their muscle-building and strength-increasing properties in high, nontherapeutic, dosages …

In addition to determining biological sex, sex hormones are known to influence health and
disease via regulation of immune cell activities and modulation of target-organ susceptibility …

Steroid hormone receptors mediate numerous crucial biological processes and are
classically thought to function as transcriptional regulators in the nucleus. However, it has …

The actions of androgens such as testosterone and dihydrotestosterone are mediated via
the androgen receptor (AR), a ligand-dependent nuclear transcription factor and member of …

Interactions between bone and the reproductive system have until now been thought to be
limited to the regulation of bone remodeling by the gonads. We now show that, in males …

In 2005, the International Union of Basic and Clinical Pharmacology Committee on Receptor
Nomenclature and Drug Classification (NC-IUPHAR) published a catalog of all of the human …

The role of androgen receptor (AR) activation and expression is well understood in prostate
cancer. In breast cancer, expression and activation of AR is increasingly recognized for its …

Dermal papilla cells (DPCs) taken from male androgenetic alopecia (AGA) patients undergo
premature senescence in vitro in association with the expression of p16 INK4a, suggesting …

An increasing amount of data indicate that osteocalcin is an endocrine hormone which
regulates energy metabolism, male fertility and brain development. However, the detailed …

G protein-coupled receptors (GPCRs) are usually highlighted as being both the largest
family of membrane proteins and the most productive source of drug targets. However, most …