Post translational modifications (PTMs) are involved in variety of cellular activities and
phosphorylation is one of the most extensively studied PTM, which regulates a number of …

After a quarter century of rapid advances, cancer research has generated a rich and
complex body of knowledge, revealing cancer to be a disease involving dynamic changes in …

In human tissues, normal homeostasis requires intricately balanced interactions between
cells and the network of secreted proteins known as the extracellular matrix. These …

Smad proteins play a key role in the intracellular signalling of transforming growth factor β
(TGFβ), which elicits a large variety of cellular responses. Upon TGFβ receptor activation …

Densely methylated DNA associates with transcriptionally repressive chromatin
characterized by the presence of underacetylated histones 1, 2. Recently, these two …

Among cell cycle regulatory proteins that are activated following DNA damage, the cyclin-
dependent kinase inhibitor p21CDKN1A plays essential roles in the DNA damage response …

Transforming growth factor beta (TGF-β) is a ubiquitous and essential regulator of cellular
and physiologic processes including proliferation, differentiation, migration, cell survival …

Transforming growth factor-β (TGF-β) is a secreted polypeptide that signals via receptor
serine/threonine kinases and intracellular Smad effectors. TGF-β inhibits proliferation and …

Transforming growth factor‐β (TGF‐β) superfamily members are multifunctional cell‐cell
signaling proteins that play pivotal roles in tissue homeostasis and development of …

Deregulated expression of c-myc can induce cell proliferation in established cell lines and in
primary mouse embryonic fibroblasts (MEFs), through a combination of both transcriptional …