Monoamine oxidase inhibitory activity of methoxy-substituted chalcones
The MAO-B inhibitory activity of chalcone (1, 3-diphenyl-2-propen-1-one) based compounds
arise from its structural similarity with 1, 4-diphenyl-2-butene, a known MAO-B inhibitor …
arise from its structural similarity with 1, 4-diphenyl-2-butene, a known MAO-B inhibitor …
Understanding the Molecular Determinant of Reversible Human Monoamine Oxidase B Inhibitors Containing 2H-Chromen-2-One Core: Structure-Based and Ligand …
M Mladenovic, A Patsilinakos, A Pirolli… - Journal of chemical …, 2017 - ACS Publications
Monoamine oxidase B (MAO B) catalyzes the oxidative deamination of aryalkylamines
neurotransmitters with concomitant reduction of oxygen to hydrogen peroxide …
neurotransmitters with concomitant reduction of oxygen to hydrogen peroxide …
Pharmacophore-based 3D-QSAR analysis of thienyl chalcones as a new class of human MAO-B inhibitors: investigation of combined quantum chemical and …
Selective monoamine oxidase-B (MAO-B) inhibitors are imperative in the treatment of
various neurodegenerative disorders. Herein, we describe the pharmacophore generation …
various neurodegenerative disorders. Herein, we describe the pharmacophore generation …
[HTML][HTML] Molecular docking analysis and dynamics simulation of salbutamol with the monoamine oxidase B (MAO-B) enzyme
The monoamine oxidase B (MAO-B) enzyme is linked with Parkinson's disease. Therefore, it
is of interest to document the molecular docking analysis and dynamics simulation of …
is of interest to document the molecular docking analysis and dynamics simulation of …
Discovery of camptothecin based topoisomerase I inhibitors: Identification using an atom based 3D-QSAR, pharmacophore modeling, virtual screening and molecular …
S Dev, SR Dhaneshwar… - Combinatorial chemistry & …, 2016 - ingentaconnect.com
Background: Camptothecin is a quinoline alkaloid, isolated from the Chinese tree
Camptotheca acuminate which exhibits its cytotoxic activity by the inhibition of nuclear …
Camptotheca acuminate which exhibits its cytotoxic activity by the inhibition of nuclear …
Design, synthesis, in vitro and in silico evaluation of new pyrrole derivatives as monoamine oxidase inhibitors
In an effort to develop potent monoamine oxidase (MAO) inhibitors, new pyrrole derivatives
were obtained via the selective reduction of the C C bonds of 1‐(1‐methyl‐1H‐pyrrol‐2‐yl) …
were obtained via the selective reduction of the C C bonds of 1‐(1‐methyl‐1H‐pyrrol‐2‐yl) …
Inhibitions of monoamine oxidases and acetylcholinesterase by 1-methyl, 5-phenyl substituted thiosemicarbazones: Synthesis, biochemical, and computational …
GE Mathew, JM Oh, K Mohan, MV Kumudhavalli… - Process …, 2020 - Elsevier
A series of eleven 1-methyl, 5-phenyl substituted thiosemicarbazones (MT1–MT11) with the
phenyl ring substitutions were prepared and investigated for their inhibitory activities against …
phenyl ring substitutions were prepared and investigated for their inhibitory activities against …
Cholinesterase inhibitory activities of selected halogenated thiophene chalcones
Background: Dual-acting human monoamine oxidase B (hMAO-B) and cholinesterase (ChE)
inhibitors are more effective than the classic one-drug one-target therapy for Alzheimer's …
inhibitors are more effective than the classic one-drug one-target therapy for Alzheimer's …
Quantitative structure-activity relationship (Qsar) studies for the inhibition of maos
M Ramesh, A Muthuraman - Combinatorial Chemistry & High …, 2020 - ingentaconnect.com
Monoamine oxidases are the crucial drug targets for the treatment of neurodegenerative
disorders like depression, Parkinson's disease, and Alzheimer's disease. The enzymes …
disorders like depression, Parkinson's disease, and Alzheimer's disease. The enzymes …
Yeni Kolinesteraz ve Monoamin Oksidaz Enzim Inhibitörlerinin Tasarımı, Sentezi ve Biyolojik Aktivite Çalışmaları
BU Polat - 2022 - search.proquest.com
Demansın en yaygın nedeni olarak görülen Alzheimer hastalığı, bilişsel fonksiyonları
etkileyen progresif ve dejeneratif bir hastalıktır. Halen kullanılmakta olan tedaviler azalmış …
etkileyen progresif ve dejeneratif bir hastalıktır. Halen kullanılmakta olan tedaviler azalmış …