Transformed cells must acquire specific characteristics to be malignant. Weinberg and
Hanahan characterize these characteristics as cancer hallmarks. Though these features are …

Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …

In vitro drug release testing is an important quality control tool for formulation development.
However, the literature has evidence that poly-lactide-co-glycolide (PLGA)-based …

Developing tunable materials which exhibit sustained drug release is a considerable
challenge. Herein, we report the concept of Therapeutic Coordination Polymers (TCPs); non …

Three novel paliperidone sulfonate salts, including salt 1 (paliperidone methanesulfate), salt
2 (paliperidone benzenesulfate), and salt 3 (paliperidone p-toluenesulfate), were …

Using a one-factor-at-a-time approach for dissolution method and discrimination analysis
can be time-consuming and may not yield the optimal and discriminative method. To …

Background/Objectives: The aim of the present study was to develop lactose-free
formulations of rivaroxaban, a novel oral anticoagulant used for the treatment and …

Purpose pH-dependent drug-drug interactions (DDIs) with poorly soluble, weakly basic
drugs may lead to clinical implications. Dasatinib is a tyrosine kinase inhibitor with reduced …

Using an artificial stomach and duodenum (ASD), we investigated the pH-dependent
precipitation of erlotinib (ERL) during dissolution in the gastrointestinal (GI) tract by varying …

The use of the surfactant, sodium lauryl sulfate (SLS), instead of enhancing drug dissolution,
deteriorates the dissolution of some alkaline drugs through forming poorly soluble lauryl …