Efforts to discover new cancer drugs and predict their clinical activity are limited by the fact
that laboratory models to test drug efficacy do not faithfully recapitulate this complex disease …

Over the past few years, establishment and adaptation of cell-based assays for drug
development and testing has become an important topic in high-throughput screening …

Although used in academic research for several decades, 3D culture models have long
been regarded expensive, cumbersome and unnecessary in drug development processes …

Breast cancer progression involves genetic changes and changes in the extracellular matrix
(ECM). To test the importance of the ECM in tumor cell dissemination, we cultured …

Purpose: To give a state-of-the-art overview on the promise of three-dimensional (3-D)
culture systems for anticancer drug development, with particular emphasis on multicellular …

While there is much literature on differentiation—loosely defined as the gain of a single or a
series of functions—we know much less about the forces and the pathways that maintain …

Purpose of this study was the development of a 3D material to be used as substrate for
breast cancer cell culture. We developed composite gels constituted by different …

The human breast epithelium is a branching ductal system composed of an inner layer of
polarized luminal epithelial cells and an outer layer of myoepithelial cells that terminate in …

PURPOSE: Tumor cell genotype and phenotype have been considered the only
determinants supporting cancer growth and metastasis. This review focuses on the …

Organs are made of the organized assembly of different cell types that contribute to the
architecture necessary for functional differentiation. In those with exocrine function, such as …