The solute carrier (SLC) superfamily comprises more than 400 transport proteins mediating
the influx and efflux of substances such as ions, nucleotides, and sugars across biological …

Significance: Mitochondria are the energetic, metabolic, redox, and information signaling
centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae …

Pulmonary arterial hypertension (PAH) is a progressive vascular disease with a high
mortality rate. It is characterized by an occlusive vascular remodeling due to a pro …

An ever-increasing number of studies highlight the role of uncoupling protein 2 (UCP2) in a
broad range of physiological and pathological processes. The knowledge of the molecular …

Despite significant progress in cardiovascular medicine, myocardial ischemia and infarction,
progressing eventually to the final end point heart failure (HF), remain the leading cause of …

Two major inconsistencies exist in the current neo-Darwinian evolutionary theory that
random chromosomal mutations acted on by natural selection generate new species. First …

Uncoupling proteins (UCPs) are anion carriers expressed in the mitochondrial inner
membrane that uncouple oxygen consumption by the respiratory chain from ATP synthesis …

The organizing power of energy flow is hypothesized to be the origin of biological complexity
and its decline the basis of “complex” diseases and aging. Energy flow through organic …

Mitochondria are fascinating organelles involved in various cellular-metabolic activities that
are integral for mammalian development. Although they perform diverse, yet interconnected …

Background and Objectives: Data suggest that genetic factors are associated with BMI. The
fat mass and obesity-associated (FTO) gene modulates adipogenesis through alternative …