The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy

N Ricard, S Bailly, C Guignabert… - Nature Reviews Cardiology, 2021 - nature.com
Endothelial cells are at the interface between circulating blood and tissues. This position
confers on them a crucial role in controlling oxygen and nutrient exchange and cellular …

Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease

CE Powe, RJ Levine, SA Karumanchi - Circulation, 2011 - Am Heart Assoc
Preeclampsia is a clinical syndrome defined as the new onset of hypertension and
proteinuria during the second half of pregnancy. 1 It afflicts 3% to 5% of pregnancies and is …

Obesity and preeclampsia: common pathophysiological mechanisms

P Lopez-Jaramillo, J Barajas… - Frontiers in …, 2018 - frontiersin.org
Preeclampsia is a disorder specific of the human being that appears after 20 weeks of
pregnancy, characterized by new onset of hypertension and proteinuria. Abnormal …

Etiology and pathogenesis of preeclampsia: current concepts

GA Dekker, BM Sibai - American journal of obstetrics and gynecology, 1998 - Elsevier
The etiology of preeclampsia is unknown. At present, 4 hypotheses are the subject of
extensive investigation, as follows:(1) Placental ischemia—Increased trophoblast …

The role of aspirin, heparin, and other interventions in the prevention and treatment of fetal growth restriction

KM Groom, AL David - American journal of obstetrics and gynecology, 2018 - Elsevier
Fetal growth restriction and related placental pathologies such as preeclampsia, stillbirth,
and placental abruption are believed to arise in early pregnancy when inadequate …

Endothelial dysfunction in preeclampsia

JM Roberts - Seminars in reproductive endocrinology, 1998 - thieme-connect.com
Several years ago the hypothesis was advanced that alterations of endothelial function
could explain much of the pathophysiology of preeclampsia. Since that time, extensive data …

Recent insights into the pathogenesis of pre-eclampsia

JM Roberts, KY Lain - Placenta, 2002 - Elsevier
Pre-eclampsia is more than pregnancy induced hypertension. The emerging view described
in this presentation is that pre-eclampsia is secondary to the interactions of reduced …

The role of hypoxia and hypoxia-inducible factor-1alpha in preeclampsia pathogenesis

R Tal - Biology of reproduction, 2012 - academic.oup.com
Abstract Preeclampsia affects 5%–8% of pregnancies and is the leading worldwide cause of
maternal and fetal morbidity and mortality. Preeclampsia is associated with shallow …

Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models

RA Khalil, JP Granger - American Journal of Physiology …, 2002 - journals.physiology.org
Normal pregnancy is associated with reductions in total vascular resistance and arterial
pressure possibly due to enhanced endothelium-dependent vascular relaxation and …

[HTML][HTML] Endothelial dysfunction; an important mediator in the Pathophysiology of Hypertension during Preeclampsia

B LaMarca - Minerva ginecologica, 2012 - ncbi.nlm.nih.gov
Preeclampsia is defined as new onset hypertension with proteinuria during pregnancy. It
affects approximately 5% of pregnancies in the US with a subset of those progressing into …