Intrinsic optical signal imaging of retinal physiology: a review

X Yao, B Wang - Journal of biomedical optics, 2015 - spiedigitallibrary.org
Intrinsic optical signal (IOS) imaging promises to be a noninvasive method for high-
resolution examination of retinal physiology, which can advance the study and diagnosis of …

Fast intrinsic optical signal correlates with activation phase of phototransduction in retinal photoreceptors

X Yao, TH Kim - Experimental Biology and Medicine, 2020 - journals.sagepub.com
Quantitative assessment of physiological condition of retinal photoreceptors is desirable for
better detection and treatment evaluation of eye diseases that can cause photoreceptor …

In vivo optoretinography of phototransduction activation and energy metabolism in retinal photoreceptors

G Ma, T Son, TH Kim, X Yao - Journal of biophotonics, 2021 - Wiley Online Library
The objective of this study is to verify the anatomic correlate of the second (2nd) outer retina
band in optical coherence tomography (OCT), and to demonstrate the potential of using …

Functional regulation of an outer retina hyporeflective band on optical coherence tomography images

S Gao, Y Li, D Bissig, ED Cohen, RH Podolsky… - Scientific reports, 2021 - nature.com
Human and animal retinal optical coherence tomography (OCT) images show a
hyporeflective band (HB) between the photoreceptor tip and retinal pigment epithelium …

[HTML][HTML] Geometrical scaling of the developing eye and photoreceptors and a possible relation to emmetropization and myopia

B Vohnsen - Vision Research, 2021 - Elsevier
In this study the role of vergence in relation to age-dependent scaling of eye and
photoreceptor parameters is studied. The underlying hypothesis is that the size and packing …

Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers

T Son, B Wang, D Thapa, Y Lu, Y Chen… - Biomedical optics …, 2016 - opg.optica.org
Blood flow changes are highly related to neural activities in the retina. It has been reported
that neural activity increases when flickering light stimulation of the retina is used. It is known …

Functional optical coherence tomography enables in vivo optoretinography of photoreceptor dysfunction due to retinal degeneration

TH Kim, B Wang, Y Lu, T Son, X Yao - Biomedical Optics Express, 2020 - opg.optica.org
Stimulus-evoked intrinsic optical signal (IOS), which occurs almost immediately after the
onset of retinal stimulus has been observed in retinal photoreceptors, promises to be a …

Functional Optical Coherence Tomography Enables In Vivo Physiological Assessment of Retinal Rod and Cone Photoreceptors

Q Zhang, R Lu, B Wang, JD Messinger, CA Curcio… - Scientific reports, 2015 - nature.com
Transient intrinsic optical signal (IOS) changes have been observed in retinal
photoreceptors, suggesting a unique biomarker for eye disease detection. However, clinical …

Functional optical coherence tomography of neurovascular coupling interactions in the retina

T Son, M Alam, D Toslak, B Wang, Y Lu… - Journal of …, 2018 - Wiley Online Library
Quantitative evaluation of retinal neurovascular coupling is essential for a better
understanding of visual function and early detection of eye diseases. However, there is no …

Functional optical coherence tomography of retinal photoreceptors

X Yao, T Son, TH Kim, Y Lu - Experimental Biology and …, 2018 - journals.sagepub.com
Age-related macular degeneration (AMD) is the leading cause of severe vision loss and
legal blindness. It is known that retinal photoreceptors are the primary target of AMD …