Epidemiologic and clinical research has provided a large body of evidence supporting the
developmental origins of health and disease (DOHaD), but there has been a relative dearth …

Intrauterine growth restriction (IUGR) affects 10–15% of all pregnancies worldwide. IUGR
may result from maternal, placental or fetal origin. Maternal malnutrition before and during …

A wealth of animal and human studies demonstrate that perinatal exposure to adverse
metabolic conditions–be it maternal obesity, diabetes or under-nutrition–results in …

A growing body of evidence supports the notion that epigenetic changes such as DNA
methylation and histone modifications, both involving chromatin remodeling, contribute to …

The concept that postnatal health and development can be influenced by events that occur
in utero originated from epidemiological studies in humans supported by numerous …

Epidemiology formed the basis of 'the Barker hypothesis', the concept of 'developmental
programming'and today's discipline of the Developmental Origins of Health and Disease …

Nonalcoholic fatty liver disease (NAFLD) is the main liver disease worldwide, and its
prevalence in children and adolescents has been increasing in the past years. It has been …

Intrauterine growth restriction (IUGR) of the fetus, resulting from placental insufficiency (PI),
is characterized by low fetal oxygen and nutrient concentrations that stunt growth rates of …

The research field of fetal programming has developed tremendously over the years and
increasing knowledge suggests that both maternal and paternal unbalanced diet can have …

Maternal obesity has risen dramatically over the past 20years, by nearly 42% in African-
Americans and 29% in Caucasians. Maternal obesity is afflicted with many maternal …