Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …

The increasing global prevalence of type 2 diabetes mellitus (T2DM) and chronic kidney
disease (CKD) has prompted research efforts to tackle the growing epidemic of diabetic …

Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …

Focal segmental glomerulosclerosis (FSGS) describes both a common lesion in progressive
kidney disease, and a disease characterized by marked proteinuria and podocyte injury …

Loss of podocytes underlies progression of CKD. Detachment of podocytes from the
glomerular basement membrane (GBM) rather than apoptosis or necrosis seems to be the …

The bidirectional causality between kidney injury and inflammation remains an area of
unexpected discoveries. The last decade unraveled the molecular mechanisms of sterile …

Kidney aging is associated with an increasing proportion of globally scarred glomeruli,
decreasing renal function, and exponentially increasing ESRD prevalence. In model …

Podocytes are unique, highly specialized, terminally differentiated cells that are integral
components of the kidney glomerular filtration barrier. Podocytes are vulnerable to a variety …

Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly
affecting the biology and function of several renal cell types including podocytes, mesangial …