Clinical epigenetics: seizing opportunities for translation

M Berdasco, M Esteller - Nature Reviews Genetics, 2019 - nature.com
Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …

Molecular basis of epstein–barr virus latency establishment and lytic reactivation

T Murata, A Sugimoto, T Inagaki, Y Yanagi… - Viruses, 2021 - mdpi.com
Epstein–Barr virus (EBV) is a causative agent of infectious mononucleosis and several types
of cancer. Like other herpesviruses, it establishes an asymptomatic, life-long latent infection …

[HTML][HTML] Epigenome-wide association study of COVID-19 severity with respiratory failure

MC de Moura, V Davalos, L Planas-Serra… - …, 2021 - thelancet.com
Background Patients infected with the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide …

Cancer epigenetics reaches mainstream oncology

M Rodríguez-Paredes, M Esteller - Nature medicine, 2011 - nature.com
Epigenetics is one of the most promising and expanding fields in the current biomedical
research landscape. Since the inception of epigenetics in the 1940s, the discoveries …

[HTML][HTML] Cervical cancer screening in developing countries at a crossroad: Emerging technologies and policy choices

R Catarino, P Petignat, G Dongui… - World journal of clinical …, 2015 - ncbi.nlm.nih.gov
Cervical cancer (CC) represents the fourth most common malignancy affecting women all
over the world and is the second most common in developing areas. In these areas, the …

Clinical implications of (epi) genetic changes in HPV-induced cervical precancerous lesions

RDM Steenbergen, PJF Snijders… - Nature Reviews …, 2014 - nature.com
Infection of cervical epithelium with high-risk human papilloma virus (hrHPV) might result in
productive or transforming cervical intraepithelial neoplasia (CIN) lesions, the morphology of …

A DNA methylation fingerprint of 1628 human samples

AF Fernandez, Y Assenov, JI Martin-Subero… - Genome …, 2012 - genome.cshlp.org
Most of the studies characterizing DNA methylation patterns have been restricted to
particular genomic loci in a limited number of human samples and pathological conditions …

Molecular mechanisms underlying human papillomavirus E6 and E7 oncoprotein-induced cell transformation

S Mittal, L Banks - Mutation Research/Reviews in Mutation Research, 2017 - Elsevier
Human papillomaviruses (HPVs) are the causative agents of 5% of all human cancers, with
cervical cancer being the most important. Two viral oncoproteins, E6 and E7, are essential …

Understanding the HPV integration and its progression to cervical cancer

MA Oyervides-Muñoz, AA Pérez-Maya… - Infection, Genetics and …, 2018 - Elsevier
Cervical cancer is one of the main causes of female cancer death worldwide, and human
papilloma virus (HPV) its causal agent. To investigate viral oncogenesis several studies …

Environmental epigenetics and its implication on disease risk and health outcomes

SM Ho, A Johnson, P Tarapore, V Janakiram… - ILAR …, 2012 - academic.oup.com
This review focuses on how environmental factors through epigenetics modify disease risk
and health outcomes. Major epigenetic events, such as histone modifications, DNA …