Conspectus Steroids continue to play a significant role in organic chemistry, medicinal
chemistry, and drug discovery due to their important biological activities and diverse …

Conspectus Steroids, termed “keys to life” by Rupert Witzmann, have a wide variety of
biological activities, including anti-inflammatory, antishock, immunosuppressive, stress …

The first and asymmetric total synthesis of bufogargarizins A and B, two unusual and highly
oxygenated twin steroids with rearranged A/B rings, was achieved. The synthetically …

Site-selective and product chemoselective aliphatic C–H bond oxidation of 1, 2-diols and of
polyhydroxylated substrates using iron and manganese catalysts and hydrogen peroxide as …

Bufospirostenin A, which was the first spirostanol to be isolated from an animal, possesses
an unprecedented 5/7/6/5/5/6 hexacyclic framework. Herein, we report two biomimetic …

Phomarol is a structurally unusual 1 (10→ 19) abeo-steroid with a pseudo-symmetrical
cycloheptene-1, 3-diol motif, an aromatic B ring, and a densely functionalized …

Pinnigorgiols B and E are 9, 11-secosteroids with a unique tricyclic γ-diketone framework.
Herein, we report the first synthesis of these natural products from inexpensive …

An enantioselective semisynthesis of (−)-bufospirostenin A is described. The key steps in the
synthesis involve use of our proposed biomimetic and diastereoselective photosantonin …

The first and asymmetric total synthesis of bioactive bufospirostenin A, an unusual
spirostanol with rearranged A/B rings, was accomplished. The synthetically challenging [5–7 …

A 10-step gram-scale synthesis of 9, 11-secosteroid pinnisterol E from the inexpensive
ergosterol is reported. This synthesis features a series of highly selective redox …