The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM)
macromolecules filled with a collection of cells including cancer-associated fibroblasts …

Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to
be a challenge in cancer treatment. Chemoresistance is influenced by genetic and …

Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well.
Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which …

Myofibroblasts are the key players in extracellular matrix remodeling, a core phenomenon in
numerous devastating fibrotic diseases. Not only in organ fibrosis, but also the pivotal role of …

There is increasing evidence that the spatial organization of cells within the tumor-immune
microenvironment (TiME) of solid tumors influences survival and response to therapy in …

Complex interactions take place during cancer formation and progression. In this regard,
there has been increasing focus on the non-malignant cells that make up the tumour …

Head and neck squamous cell carcinoma (HNSCC) is among the most severe and complex
malignant diseases with a high level of heterogeneity and, as a result, a wide range of …

Aim To perform a meta‐analysis to assess whether the presence of cancer‐associated
fibroblasts (CAF) is a prognostic marker of oral squamous cell carcinomas (OSCC). Methods …

Integrin α11β1 is a collagen receptor that has been reported to be overexpressed in the
stroma of non-small cell lung cancer (NSCLC) and of head and neck squamous cell …