The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

KS Swanson, GR Gibson, R Hutkins… - Nature Reviews …, 2020 - nature.com
Abstract In May 2019, the International Scientific Association for Probiotics and Prebiotics
(ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the …

Gut microbiota and complications of type-2 diabetes

CO Iatcu, A Steen, M Covasa - Nutrients, 2021 - mdpi.com
The gut microbiota has been linked to the emergence of obesity, metabolic syndrome and
the onset of type 2 diabetes through decreased glucose tolerance and insulin resistance …

[HTML][HTML] Classification of uremic toxins and their role in kidney failure

MH Rosner, T Reis, F Husain-Syed… - Clinical Journal of the …, 2021 - journals.lww.com
Advances in our understanding of uremic retention solutes, and improvements in
hemodialysis membranes and other techniques designed to remove uremic retention …

Uremic toxins in the progression of chronic kidney disease and cardiovascular disease: mechanisms and therapeutic targets

YJ Lim, NA Sidor, NC Tonial, A Che, BL Urquhart - Toxins, 2021 - mdpi.com
Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in
kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting …

The impact of CKD on uremic toxins and gut microbiota

J Rysz, B Franczyk, J Ławiński, R Olszewski… - Toxins, 2021 - mdpi.com
Numerous studies have indicated that the progression of chronic kidney disease (CKD) to
end-stage renal disease (ESRD) is strictly associated with the accumulation of toxic …

Inflammation‐related mechanisms in chronic kidney disease prediction, progression, and outcome

S Mihai, E Codrici, ID Popescu… - Journal of …, 2018 - Wiley Online Library
Persistent, low‐grade inflammation is now considered a hallmark feature of chronic kidney
disease (CKD), being involved in the development of all‐cause mortality of these patients …

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

D Mafra, NA Borges, B Lindholm, PG Shiels… - Nature Reviews …, 2021 - nature.com
The observation that unhealthy diets (those that are low in whole grains, fruits and
vegetables, and high in sugar, salt, saturated fat and ultra-processed foods) are a major risk …

Association of metabolic dysfunction-associated fatty liver disease with kidney disease

TY Wang, RF Wang, ZY Bu, G Targher… - Nature Reviews …, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in more
than 5% of hepatocytes in the absence of excessive alcohol consumption and other …

The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease

T Yang, EM Richards, CJ Pepine… - Nature Reviews …, 2018 - nature.com
Crosstalk between the gut microbiota and the host has attracted considerable attention
owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly …

Faecalibacterium prausnitzii Attenuates CKD via Butyrate-Renal GPR43 Axis

HB Li, ML Xu, XD Xu, YY Tang, HL Jiang, L Li… - Circulation …, 2022 - Am Heart Assoc
Background: Despite available clinical management strategies, chronic kidney disease
(CKD) is associated with severe morbidity and mortality worldwide, which beckons new …