Abstract The European Collaborative on Personalized Early Detection and Prevention of
Breast Cancer (ENVISION) brings together several international research consortia working …

Breast cancer is a heterogeneous disease, divisible into a variable number of clinical
subtypes. A fundamental question is how many etiological classes underlie the clinical …

Deciphering the shared genetic basis of distinct cancers has the potential to elucidate
carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we …

Background: Data for multiple common susceptibility alleles for breast cancer may be
combined to identify women at different levels of breast cancer risk. Such stratification could …

Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …

Importance Rare germline genetic variants in several genes are associated with increased
breast cancer (BC) risk, but their precise contributions to different disease subtypes are …

Genome-wide association studies have identified more than 70 common variants that are
associated with breast cancer risk. Most of these variants map to non-protein-coding regions …

Breast cancer is the most common cancer among women. To date, 22 common breast
cancer susceptibility loci have been identified accounting for∼ 8% of the heritability of the …

Triple-negative breast cancers (TNBC), defined by the absence of estrogen receptor,
progesterone receptor, and HER-2 expression, account for 12% to 24% of all breast …

Background: The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation
Algorithm (BOADICEA) is a risk prediction model that is used to compute probabilities of …