Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix
leucine zipper transcription factors, is an established central regulator of the …

Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …

Autophagy is a self-eating cellular catabolic pathway, through which long-lived proteins,
damaged organelles and misfolded proteins are degraded and recycled for the …

Epithelial–mesenchymal plasticity contributes to many biological processes, including tumor
progression. Various epithelial–mesenchymal transition (EMT) responses have been …

Background: Chronic activation of the innate immune system drives inflammation and
contributes directly to atherosclerosis. We previously showed that macrophages in the …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Cellular senescence is frequently evident at etiologic sites of chronic diseases and involves
essentially irreversible arrest of cell proliferation, increased protein production, resistance to …

Background Necroptosis, a recently discovered programmed cell death, has been
pathologically linked to various diseases and is thus a promising target for treating diseases …

Macroautophagy (hereafter autophagy) is an evolutionarily‐ancient mechanism by which
cellular material is delivered to lysosomes for degradation. Autophagy and cell death are …

Alcoholic liver disease (ALD) develops in approximately 20% of alcoholic patients, with a
higher prevalence in females. ALD progression is marked by fatty liver and hepatocyte …