The incidence of necrotising soft-tissue infections has increased during recent decades such
that most physicians might see at least one case of these potentially life-threatening …

Background Necrotizing skin and soft-tissue infections (NSTI) are rare but potentially life-
threatening and disabling infections that often require intensive care unit admission …

At 2.8 million infections due to AR pathogens and 35,900 attributable deaths each year (2),
AR is still a very real problem in the United States. Given that sicker patients not only tend to …

Background Clindamycin is strongly recommended as an adjunctive treatment to β-lactam
antibiotics in patients with severe invasive group A β-haemolytic streptococcal (iGAS) …

Abstract Group A Streptococcus (GAS) necrotizing soft tissue infections and toxic shock
syndrome remain high-mortality conditions. In vitro and animal model data, as well as …

Group A Streptococcus (GAS; Streptococcus pyogenes) is a nearly ubiquitous human
pathogen responsible for a significant global disease burden. No vaccine exists, so …

Variants of SARS-CoV-2 have emerged that are more transmissible than the original virus or
that exhibit some properties of immune escape, or both. The beta (B. 1.351) variant has …

Background Treatment of severe group A Streptococcus (GAS) infections requires timely
and appropriate antibiotic therapy. We describe the epidemiology of antimicrobial-resistant …

Background Public health guidance recommending isolation of individuals with group A
streptococcal (GAS) infection or carriage for 12–24 h from antibiotic initiation to prevent …

Necrotizing soft tissue infections (NSTIs) are rare life-threatening bacterial infections
characterized by an extensive necrosis of skin and subcutaneous tissues. Initial urgent …