Losing DNA methylation at repetitive elements and breaking bad
XG Pappalardo, V Barra - Epigenetics & chromatin, 2021 - Springer
Background DNA methylation is an epigenetic chromatin mark that allows heterochromatin
formation and gene silencing. It has a fundamental role in preserving genome stability …
formation and gene silencing. It has a fundamental role in preserving genome stability …
DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications
KK Wong - Cellular Oncology, 2020 - Springer
Background Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) is one of the
most devastating cancer types with a 5-year survival rate of only 9%. PDAC is one of the …
most devastating cancer types with a 5-year survival rate of only 9%. PDAC is one of the …
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
DNA methylation is a key epigenetic modification involved in regulating gene expression
and maintaining genomic integrity. Here we inactivated all three catalytically active DNA …
and maintaining genomic integrity. Here we inactivated all three catalytically active DNA …
The genome-wide mutational consequences of DNA hypomethylation
N Besselink, J Keijer, C Vermeulen, S Boymans… - Scientific Reports, 2023 - nature.com
DNA methylation is important for establishing and maintaining cell identity and for genomic
stability. This is achieved by regulating the accessibility of regulatory and transcriptional …
stability. This is achieved by regulating the accessibility of regulatory and transcriptional …
Patterns of Aneuploidy and Signaling Consequences in Cancer
N Zhakula-Kostadinova, AM Taylor - Cancer Research, 2024 - aacrjournals.org
Aneuploidy, or a change in the number of whole chromosomes or chromosome arms, is a
near-universal feature of cancer. Chromosomes affected by aneuploidy are not random, with …
near-universal feature of cancer. Chromosomes affected by aneuploidy are not random, with …
Chromatin epigenetics and nuclear lamina keep the nucleus in shape: Examples from natural and accelerated aging
PS Carollo, V Barra - Biology of the Cell, 2023 - Wiley Online Library
As the repository of genetic information, the cell nucleus must protect DNA integrity from
mechanical stresses. The nuclear lamina, which resides within the nuclear envelope (NE), is …
mechanical stresses. The nuclear lamina, which resides within the nuclear envelope (NE), is …
Glioblastoma and methionine addiction
ML Sowers, LC Sowers - International journal of molecular sciences, 2022 - mdpi.com
Glioblastoma is a fatal brain tumor with a bleak prognosis. The use of chemotherapy,
primarily the alkylating agent temozolomide, coupled with radiation and surgical resection …
primarily the alkylating agent temozolomide, coupled with radiation and surgical resection …
Loss of the methyl-CpG–binding protein ZBTB4 alters mitotic checkpoint, increases aneuploidy, and promotes tumorigenesis
A Roussel-Gervais, I Naciri, O Kirsh, L Kasprzyk… - Cancer Research, 2017 - AACR
Chromosome segregation during mitosis is monitored by the mitotic checkpoint and is
dependent upon DNA methylation. ZBTB4 is a mammalian epigenetic regulator with high …
dependent upon DNA methylation. ZBTB4 is a mammalian epigenetic regulator with high …
Epigenomics as potential tools for enhancing magnitude of breeding approaches for developing climate resilient chickpea
Epigenomics has become a significant research interest at a time when rapid environmental
changes are occurring. Epigenetic mechanisms mainly result from systems like DNA …
changes are occurring. Epigenetic mechanisms mainly result from systems like DNA …
DNMT1 is associated with cell cycle and DNA replication gene sets in diffuse large B-cell lymphoma
Abstract Dysregulation of DNA (cytosine-5)-methyltransferase 1 (DNMT1) is associated with
the pathogenesis of various types of cancer. It has been previously shown that DNMT1 is …
the pathogenesis of various types of cancer. It has been previously shown that DNMT1 is …