Incertus. jl--The Julia Lego Blocks for Randomized Clinical Trial Designs

Y Ryeznik, O Sverdlov - arXiv preprint arXiv:2407.14248, 2024 - arxiv.org
In this paper, we present Insertus. jl, the Julia package that can help the user generate a
randomization sequence of a given length for a multi-arm trial with a pre-specified target …

Optimum designs for clinical trials in personalized medicine when response variance depends on treatment

BPM Duarte, AC Atkinson - Journal of Biopharmaceutical Statistics, 2024 - Taylor & Francis
We study optimal designs for clinical trials when the value of the response and its variance
depend on treatment and covariates are included in the response model. Such designs are …

Special Issue on Randomization Methods to Design and Analyze Trial Estimands, Adjust for Covariates, and Implement Efficient Designs

JJ Chipman, WF Rosenberger, O Sverdlov… - Statistics in …, 2024 - Taylor & Francis
The National Institute of Statistical Sciences (NISS) Ingram Olkin Forum on Randomization
Tests to Address Clinical Trial Disruptions, prompted by the COVID-19 pandemic, motivated …

Maximum Tolerated Imbalance Randomization: Theory and Practice

O Sverdlov, K Carter, C Cassarly, Y Ryeznik… - … : Clinical Trial Design …, 2024 - Springer
Maximum tolerated imbalance (MTI) randomization is a class of restricted randomization
procedures that control treatment imbalance within pre-specified limits while lowering …

Randomization: Theory and Practice

O Sverdlov, K Carter, C Cassarly, Y Ryeznik… - … : Clinical Trial Design … - books.google.com
Randomization in clinical trials refers to the allocation of trial participants to treatment groups
through a process governed by chance (Wittes, 2005). The merits of randomization in …