The ETS family of oncogenic transcription factors in solid tumours
Findings over the past decade have identified aberrant activation of the ETS transcription
factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene …
factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene …
A comprehensive review of glycosylated bacterial natural products
A systematic analysis of all naturally-occurring glycosylated bacterial secondary metabolites
reported in the scientific literature up through early 2013 is presented. This comprehensive …
reported in the scientific literature up through early 2013 is presented. This comprehensive …
Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
Myeloid neoplasms with erythroid or megakaryocytic differentiation include pure erythroid
leukemia, myelodysplastic syndrome with erythroid features, and acute megakaryoblastic …
leukemia, myelodysplastic syndrome with erythroid features, and acute megakaryoblastic …
Creating and screening natural product libraries
BAP Wilson, CC Thornburg, CJ Henrich… - Natural product …, 2020 - pubs.rsc.org
Covering: up to 2020 The National Cancer Institute of the United States (NCI) has initiated a
Cancer Moonshot program entitled the NCI Program for Natural Product Discovery. As part …
Cancer Moonshot program entitled the NCI Program for Natural Product Discovery. As part …
Chemical genomics reveals histone deacetylases are required for core regulatory transcription
BE Gryder, L Wu, GM Woldemichael, S Pomella… - Nature …, 2019 - nature.com
Identity determining transcription factors (TFs), or core regulatory (CR) TFs, are governed by
cell-type specific super enhancers (SEs). Drugs to selectively inhibit CR circuitry are of high …
cell-type specific super enhancers (SEs). Drugs to selectively inhibit CR circuitry are of high …
Next steps for adolescent and young adult oncology workshop: an update on progress and recommendations for the future
AW Smith, NL Seibel, DR Lewis, KH Albritton… - Cancer, 2016 - Wiley Online Library
Each year, 70,000 adolescents and young adults (AYAs) between ages 15 and 39 years in
the United States are diagnosed with cancer. In 2006, a National Cancer Institute (NCI) …
the United States are diagnosed with cancer. In 2006, a National Cancer Institute (NCI) …
Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells
GA Franzetti, K Laud-Duval, W Van Der Ent, A Brisac… - Oncogene, 2017 - nature.com
Ewing sarcoma is characterized by the expression of the chimeric EWSR1-FLI1 transcription
factor. Proteomic analyses indicate that the decrease of EWSR1-FLI1 expression leads to …
factor. Proteomic analyses indicate that the decrease of EWSR1-FLI1 expression leads to …
Bacteria as a treasure house of secondary metabolites with anticancer potential
CD Mohan, S Rangappa, SC Nayak… - Seminars in cancer …, 2022 - Elsevier
Cancer stands in the frontline among leading killers worldwide and the annual mortality rate
is expected to reach 16.4 million by 2040. Humans suffer from about 200 different types of …
is expected to reach 16.4 million by 2040. Humans suffer from about 200 different types of …
Children's Oncology Group's 2013 blueprint for research: bone tumors
In the US, approximately 650 children are diagnosed with osteosarcoma and Ewing
sarcoma (ES) each year. Five‐year survival ranges from 65% to 75% for localized disease …
sarcoma (ES) each year. Five‐year survival ranges from 65% to 75% for localized disease …
BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells
Abstract Long interspersed element-1 (LINE-1, or L1) is the only autonomous
retrotransposon that is active in human cells. Different host factors have been shown to …
retrotransposon that is active in human cells. Different host factors have been shown to …