Advanced MRI in cerebral small vessel disease

H Van Den Brink, FN Doubal… - International Journal of …, 2023 - journals.sagepub.com
Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia. This review
summarizes recent developments in advanced neuroimaging of cSVD with a focus on …

Imaging biomarkers of VCI: a focused update

U Clancy, AK Kancheva, MCV Hernández… - Stroke, 2024 - journals.lww.com
Vascular cognitive impairment is common after stroke, in memory clinics, medicine for the
elderly services, and undiagnosed in the community. Vascular disease is said to be the …

Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised …

A Kopczak, MS Stringer, H van den Brink… - The Lancet …, 2023 - thelancet.com
Background Hypertension is the leading risk factor for cerebral small vessel disease. We
aimed to determine whether antihypertensive drug classes differentially affect microvascular …

Imaging subtle leaks in the blood–brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions

A Montagne, SR Barnes, DA Nation, K Kisler, AW Toga… - Geroscience, 2022 - Springer
Recent studies using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)
with gadolinium-based contrast agents (GBCA) have demonstrated subtle blood–brain …

Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease

S Rudilosso, MS Stringer… - Journal of Cerebral …, 2023 - journals.sagepub.com
Blood-brain barrier (BBB) is known to be impaired in cerebral small vessel disease (SVD),
and is measurable by dynamic-contrast enhancement (DCE)-MRI. In a cohort of 69 patients …

Prevalence and significance of the vessel-cluster sign on susceptibility-weighted imaging in patients with severe small vessel disease

S Rudilosso, E Chui, MS Stringer, M Thrippleton… - Neurology, 2022 - AAN Enterprises
Background and Objectives Magnetic resonance susceptibility-weighted imaging (SWI) can
identify small brain blood vessels that contain deoxygenated blood due to its induced …

The EffecTs of amlodipine and other blood PREssure lowering agents on microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: study protocol for a …

A Kopczak, MS Stringer… - European Stroke …, 2023 - journals.sagepub.com
Background: Hypertension is the leading modifiable risk factor for cerebral small vessel
diseases (SVDs). Yet, it is unknown whether antihypertensive drug classes differentially …

CVR-MRICloud: An online processing tool for CO2-inhalation and resting-state cerebrovascular reactivity (CVR) MRI data

P Liu, Z Baker, Y Li, Y Li, J Xu, DC Park, BG Welch… - PloS one, 2022 - journals.plos.org
Cerebrovascular Reactivity (CVR) provides an assessment of the brain's vascular reserve
and has been postulated to be a sensitive marker in cerebrovascular diseases. MRI-based …

Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease

MS Stringer, GW Blair, A Kopczak… - Annals of …, 2024 - Wiley Online Library
Objective Cerebral small vessel diseases (SVDs) are associated with cerebrovascular
dysfunction, such as increased blood–brain barrier leakage (permeability surface area …

Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease

J Bennett, M van Dinther, P Voorter, W Backes… - Medicina, 2023 - mdpi.com
The objective of this review is to investigate the commonalities of microvascular (small
vessel) disease in heart failure with preserved ejection fraction (HFpEF) and cerebral small …