Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of
the large number of genes and alleles attributed to DCM, comprehensive genetic testing …

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease.
HCM is a highly complex and heterogeneous disease regarding not only the number of …

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, sudden cardiac death and
heart transplant. DCM is inherited in approximately 50% of cases, in which the most frequent …

At least one-half of the growing heart failure population consists of heart failure with
preserved ejection fraction (HFpEF). The limited therapeutic options, the complexity of the …

Heart failure (HF) is a complex clinical syndrome defined by the inability of the heart to pump
enough blood to meet the body's metabolic demands. Major causes of HF are …

Background Truncating variants in the TTN gene (TTN tv) are common in patients with
dilated cardiomyopathy (DCM) but also occur in the general population. Whether TTN tv are …

Titin is the largest human protein and an essential component of the cardiac sarcomere.
With multiple immunoglobulin (Ig)-like domains that serve as molecular springs, titin …

Background Dilated cardiomyopathy (DCM) is the result of maladaptive cardiac remodeling,
which involves microRNA regulation. In turn, microRNAs can contribute to the remodeling …

The diversity in clinical phenotypes and poor understanding of the underlying
pathophysiology of heart failure with preserved ejection fraction (HFpEF) is the main reason …

Not all TTNtv are equal, and variants in constitutively expressed exons have the greatest
likelihood of pathogenicity. The clinical significance of high-impact TTNtv is likely to differ …