We present here a review of the photochemical and electrochemical applications of multi-
site proton-coupled electron transfer (MS-PCET) in organic synthesis. MS-PCETs are redox …

Transition metal-mediated formation of C–N bonds is an essential synthetic methodology.
The discovery of the Chan–Lam amination provided a C–N bond forming process that was …

We report the development of an open-source experimental design via Bayesian
optimization platform for multi-objective reaction optimization. Using high-throughput …

General conditions for organic reactions are important but rare, and efforts to identify them
usually consider only narrow regions of chemical space. Discovering more general reaction …

The exceptional versatility of sulfones has been extensively exploited in organic synthesis
across several decades. Since the first demonstration in 2005 that sulfones can participate …

A 'principles and practice'tutorial-style review of the application of solution-phase NMR in the
analysis of the mechanisms of homogeneous organic and organometallic reactions and …

Abstract The Suzuki–Miyaura cross-coupling of organoboron nucleophiles with aryl halide
electrophiles is one of the most widely used carbon–carbon bond-forming reactions in …

Boron functional groups are often introduced in place of aromatic carbon–hydrogen bonds
to expedite small-molecule diversification through coupling of molecular fragments …

A wide range of aryl boronic 1, 1, 2, 2-tetraethylethylene glycol esters [ArB (Epin) s] were
readily synthesized. Purifying aryl boronic esters by conventional silica gel chromatography …

Suzuki–Miyaura cross-couplings (SMC) are powerful tools for the construction of carbon–
carbon bonds. However, the couplings of sp3-hybridized alkyl halides with arylborons often …