A striking feature of nucleic acids and lipid membranes is that they all carry net negative
charge and so is true for the majority of intracellular proteins. It is suggested that the role of …

Proteins are important ingredients in food and feed, they are the active components of many
pharmaceutical products, and they are necessary, in the form of enzymes, for the success of …

Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

The dynamic protein corona formed on nanocarriers has been revealed to strongly affect
their in vivo behaviors. Precisely manipulating the formation of protein corona on …

The hot water and acid extracts of two different Ryugu samples collected by the Hayabusa2
mission were analyzed for the presence of aliphatic amines and amino acids. The …

Probes that covalently label protein targets facilitate the identification of ligand-binding sites.
Lysine residues are prevalent in the proteome, making them attractive substrates for …

Cell-penetrating peptides (CPPs) are promising tools for the intracellular delivery of various
biological payloads. However, the impact of payload conjugation on the cell-penetrating …

Cytokines are small signaling proteins that regulate the immune responses to infection and
tissue damage. Surface charges of cytokines determine their in vivo fate in immune …

We previously found that ribosomal protein L9 (RPL9) is a novel advanced glycation end
product (AGE)‐binding protein that can decrease pro‐inflammatory TNF‐α expression …

The molecular weight and isoelectric point of the proteins are very important parameters that
control their subcellular localization and subsequent function. Although the genome …