HSP90 inhibitors and cancer: Prospects for use in targeted therapies
ZN Li, Y Luo - Oncology reports, 2022 - spandidos-publications.com
Heat shock protein 90 (HSP90) is a vital chaperone protein, regulating signaling pathways
and correcting misfolded proteins in cancer cells by interacting with oncogenic client …
and correcting misfolded proteins in cancer cells by interacting with oncogenic client …
[HTML][HTML] Combination therapies with HSP90 inhibitors against colorectal cancer
Oncogene stability and homeostasis mediated by the HSP90 chaperone is a crucial
protection trait of cancer cells. Therefore, HSP90 represents an attractive therapeutic target …
protection trait of cancer cells. Therefore, HSP90 represents an attractive therapeutic target …
Hsp90: from cellular to organismal proteostasis
M Somogyvári, S Khatatneh, C Sőti - Cells, 2022 - mdpi.com
Assuring a healthy proteome is indispensable for survival and organismal health. Proteome
disbalance and the loss of the proteostasis buffer are hallmarks of various diseases. The …
disbalance and the loss of the proteostasis buffer are hallmarks of various diseases. The …
Heat-shock proteins in leukemia and lymphoma: multitargets for innovative therapeutic approaches
V Cabaud-Gibouin, M Durand, R Quéré, F Girodon… - Cancers, 2023 - mdpi.com
Simple Summary Heat-shock proteins (HSPs) are molecular chaperones overexpressed in
tumor cells and are necessary for their survival. In leukemia and lymphoma, HSPs have …
tumor cells and are necessary for their survival. In leukemia and lymphoma, HSPs have …
Development of a first-in-class small-molecule inhibitor of the C-terminal Hsp90 dimerization
Heat shock proteins 90 (Hsp90) are promising therapeutic targets due to their involvement in
stabilizing several aberrantly expressed oncoproteins. In cancerous cells, Hsp90 expression …
stabilizing several aberrantly expressed oncoproteins. In cancerous cells, Hsp90 expression …
Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response
Abstract Heat shock protein 90 (HSP90) stabilizes many client proteins, including the BCR-
ABL1 oncoprotein. BCR-ABL1 is the hallmark of chronic myeloid leukemia (CML) in which …
ABL1 oncoprotein. BCR-ABL1 is the hallmark of chronic myeloid leukemia (CML) in which …
Activation of MYC, a bona fide client of HSP90, contributes to intrinsic ibrutinib resistance in mantle cell lymphoma
The BTK inhibitor ibrutinib has demonstrated a remarkable therapeutic effect in mantle cell
lymphoma (MCL). However, approximately one-third of patients do not respond to the drug …
lymphoma (MCL). However, approximately one-third of patients do not respond to the drug …
Dynamically shaping chaperones. Allosteric modulators of HSP90 family as regulatory tools of cell metabolism in neoplastic progression
Molecular chaperones have recently emerged as fundamental regulators of salient
biological routines, including metabolic adaptations to environmental changes. Yet, many of …
biological routines, including metabolic adaptations to environmental changes. Yet, many of …
Recent advances in the discovery of novel HSP90 inhibitors: an update from 2014
Y Xiao, Y Liu - Current Drug Targets, 2020 - ingentaconnect.com
HSP90 is a member of the family of heat shock proteins responsible for folding proteins into
mature conformations and thus maintaining their biological function in cells. Since it is …
mature conformations and thus maintaining their biological function in cells. Since it is …
Dual targeting strategies on histone deacetylase 6 (HDAC6) and heat shock protein 90 (Hsp90)
The design of multi-target drugs acting simultaneously on multiple signaling pathways is a
growing field in medicinal chemistry, especially for the treatment of complex diseases, such …
growing field in medicinal chemistry, especially for the treatment of complex diseases, such …