Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …

Short interfering RNAs (siRNA) are a powerful class of genetic medicines whose clinical
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …

Molecularly targeted cancer therapies substantially improve patient outcomes, although the
durability of their effectiveness can be limited. Resistance to these therapies is often related …

The key proteins involved in transcriptional regulation play convergent roles in cellular
homeostasis, and their dysfunction mediates aberrant gene expressions that underline the …

The nuclear factor-κB (NF-κB) signaling pathway is one of the most well-studied pathways
related to inflammation, and its involvement in aging has attracted considerable attention. As …

RNA structures, including those formed from coding and noncoding RNAs, alternative to
protein‐based drug targets, could be a promising target of small molecules for drug …

Elucidation of protein-protein interactions (PPIs) represents one of the most important
methods in biomedical research. Recently, PPIs have started to be exploited for drug …

Cancer continues to present a substantial global health challenge, with its incidence and
mortality rates persistently reflecting its significant impact. The emergence of precision …

The gaining importance of Targeted Protein Degradation (TPD) and PROTACs (PROteolysis-
TArgeting Chimeras) have drawn the scientific community's attention. PROTACs are …

KRAS is one of the most frequently mutated oncogenes in human cancers. Despite nearly
40 years of research, KRAS remains largely undruggable, in part due to an incomplete …