Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …
century. It is a well-recognized multifactorial health problem contributes significantly to high …
Recent developments in synthetic α-glucosidase inhibitors: A comprehensive review with structural and molecular insight
Diabetes mellitus is the prominent metabolic disorder affecting 422 million people around
the globe and cause severe associated problems like kidney disorders, heart and nervous …
the globe and cause severe associated problems like kidney disorders, heart and nervous …
α‐glucosidase, α‐amylase inhibition, kinetics and docking studies of novel (2‐chloro‐6‐(trifluoromethyl) benzyloxy) arylidene) based rhodanine and rhodanine acetic …
V Kumar, R Ramu, PS Shirahatti, VBC Kumari… - …, 2021 - Wiley Online Library
In our effort to identify potent fluorinated small molecules as antidiabetic compounds, a novel
fluorinated series of 2‐chloro‐6‐(trifluoromethyl) benzyloxy arylidene derived Rhodanine …
fluorinated series of 2‐chloro‐6‐(trifluoromethyl) benzyloxy arylidene derived Rhodanine …
Exploring biological efficacy of novel benzothiazole linked 2, 5-disubstituted-1, 3, 4-oxadiazole hybrids as efficient α-amylase inhibitors: Synthesis, characterization …
In an effort to explore a class of novel antidiabetic agents, we have made an effort to
synergize the α-amylase inhibitory potential of 1, 3-benzothiazole and 1, 3, 4-oxadiazole …
synergize the α-amylase inhibitory potential of 1, 3-benzothiazole and 1, 3, 4-oxadiazole …
Design, synthesis, spectroscopic characterization, single crystal X-ray analysis, in vitro α-amylase inhibition assay, DPPH free radical evaluation and computational …
In our quest to design and develop N/O-containing inhibitors of α-amylase, we have tried to
synergize the inhibitory action of 1, 4-naphthoquinone, imidazole and 1, 2, 3-triazole motifs …
synergize the inhibitory action of 1, 4-naphthoquinone, imidazole and 1, 2, 3-triazole motifs …
Parsing structural fragments of thiazolidin-4-one based α-amylase inhibitors: A combined approach employing in vitro colorimetric screening and GA-MLR based …
Abstract α-Amylase (EC. 3.2. 1.1) is a ubiquitous digestive endoamylase. The abrupt rise in
blood glucose levels due to the hydrolysis of carbohydrates by α-amylase at a faster rate is …
blood glucose levels due to the hydrolysis of carbohydrates by α-amylase at a faster rate is …
Design and synthesis of new benzylidene-quinazolinone hybrids as potential anti-diabetic agents: In vitro α-glucosidase inhibition, and docking studies
MM Khalifa, HM Sakr, A Ibrahim, AM Mansour… - Journal of Molecular …, 2022 - Elsevier
A novel series of benzylidene-quinazolinone hybrids 8 a, b and 10 an were designed,
synthesized, and evaluated for their in vitro α-glucosidase inhibitory effect aiming to discover …
synthesized, and evaluated for their in vitro α-glucosidase inhibitory effect aiming to discover …
Crystal structure, Hirshfeld surface and DFT based NBO, NLO, ECT and MEP of benzothiazole based hydrazone
K Singh, R Kataria - Chemical Physics, 2020 - Elsevier
Benzothiazole based hydrazone was synthesised and characterised using FT-IR, 1 H NMR
& X-ray studies. The ground state geometry for the synthesised compound was predicted …
& X-ray studies. The ground state geometry for the synthesised compound was predicted …
Quantitative structure toxicity analysis of ionic liquids toward acetylcholinesterase enzyme using novel QSTR models with index of ideality of correlation and …
Ionic liquids (ILs) have enticed the curiosity of chemists due to their vast applications in
academic and industrial research. These have many advantages over other conventional …
academic and industrial research. These have many advantages over other conventional …
Pyrazole scaffold‐based derivatives: A glimpse of α‐glucosidase inhibitory activity, SAR, and route of synthesis
The α‐glucosidase is a validated target to develop drugs for treating type 2 diabetes
mellitus. The existing α‐glucosidase inhibitors have certain shortcomings related to side …
mellitus. The existing α‐glucosidase inhibitors have certain shortcomings related to side …