Mammalian cells have divergent responses to varying oxygen levels. Cells exposed to low
oxygen levels (hypoxia) activate the transcription factor hypoxia-inducible factor-1 (HIF-1) as …

The management of acute hypoxemic respiratory failure frequently includes the use of
supraphysiological fractions of inspired oxygen (FiO 2), which can be beneficial in the short …

Acute lung injury (ALI), such as that which occurs with mechanical ventilation, contributes to
morbidity and mortality of critical illness. Nonetheless, in many instances, ALI resolves …

Acute lung injury (ALI) is a lung disease characterized by pulmonary edema and severe
hypoxia. The past decade hosted a search for endogenous mechanisms controlling lung …

Here, we studied the potential role of inorganic polyphosphate (polyP) as an energy source
for ADP and ATP formation in the extracellular space. In SaOS-2 cells, we show that matrix …

Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessel walls, and
their proliferation and migration play important roles in the development of atherosclerosis …

[Frontiers in Bioscience 13, 6653-6661, May 1, 2008] 6653 Molecular mechanisms of
hyperoxia-induced acute lung injury Vineet Bh Page 1 [Frontiers in Bioscience 13, 6653-6661 …

Administration of supplemental oxygen remains a critical clinical intervention for survival of
preterm infants with respiratory failure. However, prolonged exposure to hyperoxia can …

In addition to immunological and wound healing cell and platelet delivery, ion stasis and
nutrient supply, blood delivers oxygen to cells and tissues and removes metabolic wastes …

Purinergic modulation of mesangial extracellular matrix production: Role in diabetic and
other glomerular diseases. Background Extracellular adenosine triphosphate (ATP)(eATP) …