Sepsis-induced immunosuppression

LK Torres, P Pickkers… - Annual review of …, 2022 - annualreviews.org
Sepsis is expected to have a substantial impact on public health and cost as its prevalence
increases. Factors contributing to increased prevalence include a progressively aging …

Current status of potential therapeutic candidates for the COVID-19 crisis

J Zhang, B Xie, K Hashimoto - Brain, behavior, and immunity, 2020 - Elsevier
Abstract As of April 15, 2020, the ongoing coronavirus disease 2019 (COVID-2019)
pandemic has swept through 213 countries and infected more than 1,870,000 individuals …

[HTML][HTML] Current sepsis therapeutics

JL Vincent - EBioMedicine, 2022 - thelancet.com
Management of the patient with sepsis comprises three key branches: control of the
underlying infection, haemodynamic stabilization, and modulation of the host response …

Cardiogenic shock and hyperinflammatory syndrome in young males with COVID-19

VQ Chau, G Giustino, K Mahmood… - Circulation: Heart …, 2020 - Am Heart Assoc
DISCUSSION To our knowledge, we describe the first case series of young males with
COVID-19 and elevated titers of SARS-CoV-2 Ab who presented with hyperinflammatory …

Comparative effectiveness of fludrocortisone and hydrocortisone vs hydrocortisone alone among patients with septic shock

NA Bosch, B Teja, AC Law, B Pang… - JAMA internal …, 2023 - jamanetwork.com
Importance Patients with septic shock may benefit from the initiation of corticosteroids.
However, the comparative effectiveness of the 2 most studied corticosteroid regimens …

Immune deregulation in sepsis and septic shock: reversing immune paralysis by targeting PD-1/PD-L1 pathway

Y Nakamori, EJ Park, M Shimaoka - Frontiers in immunology, 2021 - frontiersin.org
Sepsis remains a major problem for human health worldwide, thereby manifesting high rates
of morbidity and mortality. Sepsis, once understood as a monophasic sustained …

Corticosteroids for COVID-19

D Annane - Journal of Intensive Medicine, 2021 - mednexus.org
Coronavirus disease 19 (COVID-19) is placing a major burden on healthcare, economy and
social systems worldwide owing to its fast spread and unacceptably high death toll. The …

Corticosteroids for treating sepsis in children and adults

D Annane, E Bellissant, PE Bollaert… - Cochrane Database …, 2019 - cochranelibrary.com
Background Sepsis occurs when an infection is complicated by organ failure. Sepsis may be
complicated by impaired corticosteroid metabolism. Thus, providing corticosteroids may …

[PDF][PDF] 中国脓毒症早期预防与阻断急诊专家共识

共识, 解读 - 临床急诊杂志, 2020 - medi-guide.meditool.cn
中国脓毒症早期预防与阻断急诊专家共识 Page 1 2020年 临床急诊杂志 21卷7期
JournalofClinicalEmergency(China) ·共识·解读· [编者按]脓毒症是目前医学界面临的重大难题与 …

[HTML][HTML] Immunotherapy in sepsis-brake or accelerate?

F Steinhagen, SV Schmidt, JC Schewe… - Pharmacology & …, 2020 - Elsevier
Sepsis, a life threating syndrome characterized by organ failure after infection, is the most
common cause of death in hospitalized patients. The treatment of sepsis is generally …