Molecular pathways: the balance between cancer and the immune system challenges the therapeutic specificity of targeting nuclear factor-κB signaling for cancer …

KP Zeligs, MK Neuman, CM Annunziata - Clinical Cancer Research, 2016 - AACR
The NF-κB signaling pathway is a complex network linking extracellular stimuli to cell
survival and proliferation. Cytoplasmic signaling to activate NF-κB can occur as part of the …

Folate-engineered microvesicles for enhanced target and synergistic therapy toward breast cancer

L Zhu, D Dong, ZL Yu, YF Zhao, DW Pang… - … applied materials & …, 2017 - ACS Publications
As an ideal nanovector candidate, microvesicles (MVs) have been gradually utilized for
packaging kinds of functional molecules for effective tumor diagnosis and therapy; however …

Complex IIa formation and ABC transporters determine sensitivity of OSCC to Smac mimetics

Y Wang, Z Liu, Q Si, W Lu, Y Song, W Jin, X Yang… - Cell Death & …, 2024 - nature.com
Small molecule inhibitors of apoptosis proteins (IAPs) antagonists, known as Smac mimetics
(SMs), activate non-canonical NF-κB and sensitize cancer cells to TNF-induced cell death …