[HTML][HTML] Acute-on-chronic liver failure: definitions, pathophysiology and principles of treatment
G Zaccherini, E Weiss, R Moreau - JHEP Reports, 2021 - Elsevier
The term acute-on-chronic liver failure (ACLF) defines an abrupt and life-threatening
worsening of clinical conditions in patients with cirrhosis or chronic liver disease. In recent …
worsening of clinical conditions in patients with cirrhosis or chronic liver disease. In recent …
Functional proteins of mesenchymal stem cell-derived extracellular vesicles
G Qiu, G Zheng, M Ge, J Wang, R Huang… - Stem cell research & …, 2019 - Springer
Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs,
and phospholipids, and are a novel mechanism of intercellular communication. It has been …
and phospholipids, and are a novel mechanism of intercellular communication. It has been …
Cell therapy for advanced liver diseases: repair or rebuild
Advanced liver disease presents a significant worldwide health and economic burden and
accounts for 3.5% of global mortality. When liver disease progresses to organ failure the …
accounts for 3.5% of global mortality. When liver disease progresses to organ failure the …
Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization
J Wang, J Xia, R Huang, Y Hu, J Fan, Q Shu… - Stem Cell Research & …, 2020 - Springer
Mesenchymal stem cells (MSCs) are adult stromal cells that reside in virtually all postnatal
tissues. Due to their regenerative and immunomodulatory capacities, MSCs have attracted …
tissues. Due to their regenerative and immunomodulatory capacities, MSCs have attracted …
Thrombogenic risk induced by intravascular mesenchymal stem cell therapy: current status and future perspectives
L Coppin, E Sokal, X Stéphenne - Cells, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) are currently studied and used in numerous clinical trials.
Nevertheless, some concerns have been raised regarding the safety of these infusions and …
Nevertheless, some concerns have been raised regarding the safety of these infusions and …
Regenerative medicine: postnatal approaches
Paper 2 of the paediatric regenerative medicine Series focuses on recent advances in
postnatal approaches. New gene, cell, and niche-based technologies and their …
postnatal approaches. New gene, cell, and niche-based technologies and their …
Cell transplantation-based regenerative medicine in liver diseases
This review aims to evaluate the current preclinical state of liver bioengineering, the clinical
context for liver cell therapies, the cell sources, the delivery routes, and the results of clinical …
context for liver cell therapies, the cell sources, the delivery routes, and the results of clinical …
[HTML][HTML] A phase II study of human allogeneic liver-derived progenitor cell therapy for acute-on-chronic liver failure and acute decompensation
F Nevens, T Gustot, PF Laterre, LL Lasser… - JHEP Reports, 2021 - Elsevier
Background & Aims Human allogeneic liver-derived progenitor cells (HALPC, HepaStem®;
Promethera Biosciences, Mont-Saint-Guibert, Belgium) are an advanced therapy medicinal …
Promethera Biosciences, Mont-Saint-Guibert, Belgium) are an advanced therapy medicinal …
Organoid transplant approaches for the liver
Organoid technology is a state‐of‐the‐art cell culture tool that has revolutionized study of
development, regeneration, and diseases. Human liver organoids (HLOs) are now derived …
development, regeneration, and diseases. Human liver organoids (HLOs) are now derived …
Cell-based regeneration and treatment of liver diseases
The liver, in combination with a functional biliary system, is responsible for maintaining a
great number of vital body functions. However, acute and chronic liver diseases may lead to …
great number of vital body functions. However, acute and chronic liver diseases may lead to …