Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

CA Akdis - Nature Reviews Immunology, 2021 - nature.com
There has been a steep increase in allergic and autoimmune diseases, reaching epidemic
proportions and now affecting more than one billion people worldwide. These diseases are …

Epidemiology and pathogenesis of ulcerative colitis

L Du, C Ha - Gastroenterology Clinics, 2020 - gastro.theclinics.com
Ulcerative colitis (UC) is a chronic immune-mediated inflammatory disorder of the colon
(IBD) that is hypothesized to be related to exposure to environmental risk factors leading to …

Association of ultra-processed food intake with risk of inflammatory bowel disease: prospective cohort study

N Narula, ECL Wong, M Dehghan, A Mente… - Bmj, 2021 - bmj.com
Objective To evaluate the relation between intake of ultra-processed food and risk of
inflammatory bowel disease (IBD). Design Prospective cohort study. Setting 21 low, middle …

The intestinal barrier and current techniques for the assessment of gut permeability

I Schoultz, ÅV Keita - Cells, 2020 - mdpi.com
The intestinal barrier is essential in human health and constitutes the interface between the
outside and the internal milieu of the body. A functional intestinal barrier allows absorption of …

Leaky gut: mechanisms, measurement and clinical implications in humans

M Camilleri - Gut, 2019 - gut.bmj.com
The objectives of this review on 'leaky gut'for clinicians are to discuss the components of the
intestinal barrier, the diverse measurements of intestinal permeability, their perturbation in …

Environmental risk factors for inflammatory bowel diseases: an umbrella review of meta-analyses

D Piovani, S Danese, L Peyrin-Biroulet… - Gastroenterology, 2019 - Elsevier
Background & Aims Multiple environmental factors have been associated with the
development of inflammatory bowel diseases (IBDs). We performed an umbrella review of …

Early-onset colorectal cancer: initial clues and current views

LJ Hofseth, JR Hebert, A Chanda, H Chen… - Nature reviews …, 2020 - nature.com
Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in
patients< 50 years old) has increased at an alarming rate. Although robust and scientifically …

Dietary management of adults with IBD—the emerging role of dietary therapy

JA Fitzpatrick, SL Melton, CK Yao, PR Gibson… - Nature Reviews …, 2022 - nature.com
Historically, dietitians played a minor part in the management of inflammatory bowel disease
(IBD), including Crohn's disease and ulcerative colitis. Patients were commonly referred for …

A comprehensive review and update on Crohn's disease

M Gajendran, P Loganathan, AP Catinella… - Disease-a-month, 2018 - Elsevier
The term inflammatory bowel disease (IBD) refers principally to two major categories of
chronic relapsing inflammatory intestinal disorders: Crohn's disease (CD) and ulcerative …

Understanding and preventing the global increase of inflammatory bowel disease

GG Kaplan, SC Ng - Gastroenterology, 2017 - Elsevier
The inflammatory bowel diseases (IBDs) are contemporary conditions of industrialized
societies. The prevalence of IBD continues to increase steadily in Western countries, and …