The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Objectives The present study explored the effects of two prebiotics on the secretion of the
stress hormone, cortisol and emotional processing in healthy volunteers. Methods Forty-five …

Cognitive abnormalities are a core feature of depression, and biases toward negatively
toned emotional information are common, but are they a cause or a consequence of …

Since its introduction almost 20 years ago, the tail suspension test has become one of the
most widely used models for assessing antidepressant-like activity in mice. The test is based …

Methylenedioxymethamphetamine (MDMA,'ecstasy') releases serotonin and
norepinephrine. MDMA is reported to produce empathogenic and prosocial feelings. It is …

Aversive emotional reactions to real or imagined social harms infuse moral judgment and
motivate prosocial behavior. Here, we show that the neurotransmitter serotonin directly …

BackgroundThe neuropharmacological actions of antidepressants are well characterised
but our understanding of how these changes translate into improved mood are still …

Objective: Acute administration of an antidepressant increases positive affective processing
in healthy volunteers, an effect that may be relevant to the therapeutic actions of these …

Major depressive disorder (MDD) is characterized by structural and neurochemical changes
in limbic structures, including the hippocampus, that regulate mood and cognitive functions …