Therapeutic targeting of “undruggable” MYC

V Llombart, MR Mansour - EBioMedicine, 2022 - thelancet.com
Summary c-MYC controls global gene expression and regulates cell proliferation, cell
differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is …

Deubiquitinases: From mechanisms to their inhibition by small molecules

SM Lange, LA Armstrong, Y Kulathu - Molecular cell, 2022 - cell.com
Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or
cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in …

The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery

Z Fu, B Huang, J Tang, S Liu, M Liu, Y Ye, Z Liu… - Nature …, 2021 - nature.com
SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2
papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus …

The role of ubiquitination in tumorigenesis and targeted drug discovery

L Deng, T Meng, L Chen, W Wei, P Wang - Signal transduction and …, 2020 - nature.com
Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

T Klemm, G Ebert, DJ Calleja, CC Allison… - The EMBO …, 2020 - embopress.org
The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …

Deubiquitinases in cancer

G Dewson, PJA Eichhorn, D Komander - Nature Reviews Cancer, 2023 - nature.com
Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

Breaking the chains: deubiquitylating enzyme specificity begets function

MJ Clague, S Urbé, D Komander - Nature reviews Molecular cell …, 2019 - nature.com
The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …

p53 modifications: exquisite decorations of the powerful guardian

Y Liu, O Tavana, W Gu - Journal of molecular cell biology, 2019 - academic.oup.com
The last 40 years have witnessed how p53 rose from a viral binding protein to a central
factor in both stress responses and tumor suppression. The exquisite regulation of p53 …

[HTML][HTML] USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer

X Dai, L Lu, S Deng, J Meng, C Wan, J Huang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Tumor associated macrophages (TAMs) have strong plasticity and if
reprogrammed, can clear tumor cells and regulate the adaptive immune system for cancer …

Principles of ubiquitin-dependent signaling

E Oh, D Akopian, M Rape - Annual review of cell and …, 2018 - annualreviews.org
Ubiquitylation is an essential posttranslational modification that controls cell division,
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …