Protein dyshomeostasis is the common mechanism of neurodegenerative diseases such as
Alzheimer's disease (AD). Aging is the key risk factor, as the capacity of the proteostasis …

The ability of abnormal TSE-associated forms of PrP to seed the formation of amyloid fibrils
from recombinant PrPSen has served as the basis for several relatively rapid and highly …

The development and adaption of in vitro misfolded protein amplification systems has been
a major innovation in the detection of abnormally folded prion protein scrapie (PrPSc) in …

Prions are proteinaceous infectious agents responsible for the transmission of prion
diseases. The lack of a procedure for cultivating prions in the laboratory has been a major …

Among transmissible spongiform encephalopathies or prion diseases affecting humans,
sporadic forms such as sporadic Creutzfeldt–Jakob disease are the vast majority. Unlike …

The transmissible agent of prion disease consists of a prion protein in its abnormal, β-sheet
rich state (PrPSc), which is capable of replicating itself according to the template-assisted …

The central event underlying prion diseases involves conformational change of the cellular
form of the prion protein (PrPC) into the disease-associated, transmissible form (PrPSc) …

Since chronic wasting disease (CWD) was first identified nearly 50 years ago in a captive
mule deer herd in the Rocky Mountains of the United States, it has slowly spread across …

Since the term protein was first coined in 1838 and protein was discovered to be the
essential component of fibrin and albumin, all cellular proteins were presumed to play …

Human prion diseases are a unique group of transmissible neurodegenerative diseases that
occur as sporadic, familial or acquired disorders and show a wide range of phenotypic …