Blood vessels are conduits distributed throughout the body, supporting tissue growth and
homeostasis by the transport of cells, oxygen and nutrients. Endothelial cells (ECs) form the …

The drugs used for treating bone diseases (BDs), at present, elicit hazardous side effects
that include certain types of cancers and strokes, hence the ongoing quest for the discovery …

Wnt proteins modulate cell proliferation and differentiation and the self-renewal of stem cells
by inducing β-catenin-dependent signalling through the Wnt receptor frizzled (FZD) and the …

Steroid-induced osteonecrosis of the femoral head (SONFH) is a refractory disease induced
by glucocorticoids. Marrow mesenchymal stem cells (MSCs) differentiate into multiple bone …

In recent decades, the field of bone mechanobiology has sought experimental techniques to
unravel the molecular mechanisms governing the phenomenon of mechanically regulated …

Abstract Background Circular RNAs (circRNAs) are emerging as important regulators in
human disease. The expression profile and mechanism of circRNAs in postmenopausal …

Studies of cell fate focus on specification, but little is known about maintenance of the
differentiated state. In this study, we find that the mouse tendon cell fate requires continuous …

Transcription factors (TFs) regulate the expression of target genes, inducing changes in cell
morphology or activities needed for cell fate determination and differentiation. The BMP …

Increasing evidence suggests that postmenopausal osteoporosis (PMO), a severe
disturbance, imposes heavy physical, psychosocial, and financial burdens and dramatically …

Polyetheretherketone (PEEK) is considered as a potential dental and orthopedic implant
material owing to its favorable thermal and chemical stability, biocompatibility and …