Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system?

M Desforges, A Le Coupanec, P Dubeau, A Bourgouin… - viruses, 2019 - mdpi.com
Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases.
However, in vulnerable populations, such as newborns, infants, the elderly and immune …

Neurologic alterations due to respiratory virus infections

K Bohmwald, NMS Gálvez, M Ríos… - Frontiers in cellular …, 2018 - frontiersin.org
Central Nervous System (CNS) infections are one of the most critical problems in public
health, as frequently patients exhibit neurologic sequelae. Usually, CNS pathologies are …

More than a tripledemic: influenza A virus, respiratory syncytial virus, SARS-CoV-2, and human metapneumovirus in wastewater during winter 2022–2023

AB Boehm, MK Wolfe, BJ White, B Hughes… - … science & technology …, 2023 - ACS Publications
Wastewater monitoring can provide insights into respiratory disease occurrence in
communities that contribute to the wastewater system. Using daily measurements of RNA of …

Respiratory syncytial virus entry and how to block it

MB Battles, JS McLellan - Nature Reviews Microbiology, 2019 - nature.com
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in
young children and elderly people. Although the virus was isolated in 1955, an effective …

More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis

A Frey, LP Lunding, JC Ehlers, M Weckmann… - Frontiers in …, 2020 - frontiersin.org
Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …

Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer

MJG Bakkers, T Ritschel, M Tiemessen… - Nature …, 2024 - nature.com
The prefusion conformation of human metapneumovirus fusion protein (hMPV Pre-F) is
critical for eliciting the most potent neutralizing antibodies and is the preferred immunogen …

Ocular tropism of respiratory viruses

JA Belser, PA Rota, TM Tumpey - Microbiology and Molecular …, 2013 - Am Soc Microbiol
Respiratory viruses (including adenovirus, influenza virus, respiratory syncytial virus,
coronavirus, and rhinovirus) cause a broad spectrum of disease in humans, ranging from …

Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018: a systematic review and modelling …

X Wang, Y Li, M Deloria-Knoll, SA Madhi… - The Lancet Global …, 2021 - thelancet.com
Background Human metapneumovirus is a common virus associated with acute lower
respiratory infections (ALRIs) in children. No global burden estimates are available for ALRIs …

Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology

JS Tregoning, J Schwarze - Clinical microbiology reviews, 2010 - Am Soc Microbiol
In global terms, respiratory viral infection is a major cause of morbidity and mortality. Infancy,
in particular, is a time of increased disease susceptibility and severity. Early-life viral …

Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia

PCY Woo, SKP Lau, C Chu, K Chan, H Tsoi… - Journal of …, 2005 - Am Soc Microbiol
Despite extensive laboratory investigations in patients with respiratory tract infections, no
microbiological cause can be identified in a significant proportion of patients. In the past 3 …