Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In
the past decade, development of the new magnetic resonance imaging technique …

Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Friedreich ataxia is the most common of the hereditary ataxias. It is due to homozygous/
compound heterozygous mutations in FXN. This gene encodes frataxin, a protein largely …

Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive
deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is …

Background Neuroinflammation is proposed to accompany, or even contribute to,
neuropathology in Friedreich ataxia (FRDA), with implications for disease treatment and …

Friedreich ataxia (FA) is currently an incurable inherited mitochondrial disease caused by
reduced levels of frataxin (FXN). Cardiac dysfunction is the main cause of premature death …

Objective Friedreich ataxia (FRDA) is an inherited neurological disease defined by
progressive movement incoordination. We undertook a comprehensive characterization of …

Increasing evidence suggests that the peroxisome proliferator-activated receptor γ (PPARγ),
a member of the nuclear receptor superfamily, plays an important role in physiological …

The cerebellar nuclei are a brain region with high iron content. Surprisingly, little is known
about iron content in the cerebellar nuclei and its possible contribution to pathology in …

The life shortening nature of Friedreich Ataxia (FRDA) demands the search for therapies that
can delay, stop or reverse its relentless trajectory. This review provides a contemporary …