Abstract FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition
component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein) …

Alterations in protein ubiquitylation and hypoxia are commonly associated with cancer.
Ubiquitylation is carried out by three sequentially acting ubiquitylating enzymes and can be …

Human glioblastoma is the most frequent and aggressive form of brain tumour in the adult
population. Proteolytic turnover of tumour suppressors by the ubiquitin–proteasome system …

Background: F-box and WD repeat domain-containing 7 (FBXW7) is a cell cycle regulatory
gene whose protein product ubiquitinates positive cell cycle regulators such as c-Myc, cyclin …

The CCAAT/enhancer binding protein delta (CEBPD, C/EBPδ) is a transcription factor that
modulates many biological processes including cell differentiation, motility, growth arrest …

Background The E3 ubiquitin ligase Fbxw7 functions as a general tumor suppressor by
targeting several well-known oncoproteins for ubiquitination and proteasomal degradation …

Abstract Heat-shock factor 1 (HSF1) orchestrates the heat-shock response in eukaryotes.
Although this pathway has evolved to help cells adapt in the presence of challenging …

A molecular target associated with the progression of gastric cancer has not yet been
uncovered. FBXW7 is a tumor suppressor gene transcriptionally controlled by p53 that plays …

Fbw7 is a tumor suppressor frequently inactivated in cancers. The KLF5 transcription factor
promotes breast cell proliferation and tumorigenesis through upregulating FGF-BP. The …

Gliomas constitute the most frequent tumors of the brain. High-grade gliomas are
characterized by a poor prognosis caused by a set of attributes making treatment difficult …