Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment

W Li, F Li, X Zhang, HK Lin, C Xu - Signal transduction and targeted …, 2021 - nature.com
More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Protein S-nitrosylation: purview and parameters

DT Hess, A Matsumoto, SO Kim, HE Marshall… - … reviews Molecular cell …, 2005 - nature.com
S-nitrosylation, the covalent attachment of a nitrogen monoxide group to the thiol side chain
of cysteine, has emerged as an important mechanism for dynamic, post-translational …

Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance

S Lee, SM Kim, RT Lee - Antioxidants & redox signaling, 2013 - liebertpub.com
The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …

[HTML][HTML] Aberrant protein s-nitrosylation in neurodegenerative diseases

T Nakamura, S Tu, MW Akhtar, CR Sunico, S Okamoto… - Neuron, 2013 - cell.com
S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein
function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group …

Reactive oxygen species-induced activation of the MAP kinase signaling pathways

JA McCubrey, MM LaHair… - Antioxidants & redox …, 2006 - liebertpub.com
An abundance of scientific literature exists demonstrating that oxidative stress influences the
MAPK signaling pathways. This review summarizes these findings for the ERK, JNK, p38 …

Regulation by S-nitrosylation of protein post-translational modification

DT Hess, JS Stamler - Journal of Biological Chemistry, 2012 - ASBMB
Protein post-translational modification by S-nitrosylation conveys a ubiquitous influence of
nitric oxide on signal transduction in eukaryotic cells. The wide functional purview of S …

Redox regulation of protein kinases

A Corcoran, TG Cotter - The FEBS journal, 2013 - Wiley Online Library
Reactive oxygen species (ROS) have been long regarded as by‐products of a cascade of
reactions stemming from cellular oxygen metabolism, which, if they accumulate to toxic …

JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species

HM Shen, Z Liu - Free Radical Biology and Medicine, 2006 - Elsevier
c-Jun N-terminal kinase (JNK), or stress-activated protein kinase, is an important member of
the mitogen-activated protein kinase superfamily, the members of which are readily …

Nitric Oxide and Protein S-Nitrosylation Are Integral to Hydrogen Peroxide-Induced Leaf Cell Death in Rice

A Lin, Y Wang, J Tang, P Xue, C Li, L Liu, B Hu… - Plant …, 2012 - academic.oup.com
Nitric oxide (NO) is a key redox-active, small molecule involved in various aspects of plant
growth and development. Here, we report the identification of an NO accumulation mutant …

Nitric oxide, a double edged sword in cancer biology: searching for therapeutic opportunities

S Mocellin, V Bronte, D Nitti - Medicinal research reviews, 2007 - Wiley Online Library
Nitric oxide (NO) is a pleiotropic molecule critical to a number of physiological and
pathological processes. The last decade has witnessed major advances in dissecting NO …